Buchta Vladimir, Bolehovská Radka, Hovorková Eva, Cornely Oliver A, Seidel Danila, Žák Pavel
Department of Clinical Microbiology, Faculty of Medicine in Hradec Králové, Faculty Hospital in Hradec Králové, Charles University in Prague, Hradec Králové, Czechia.
Department of Clinical Biochemistry and Diagnostics, Faculty of Medicine in Hradec Králové, Faculty Hospital in Hradec Králové, Charles University in Prague, Hradec Králové, Czechia.
Front Microbiol. 2019 Oct 29;10:2196. doi: 10.3389/fmicb.2019.02196. eCollection 2019.
(formerly , now proposed as ) is a filamentous yeast-like fungus that has recently been described as an emerging pathogen mostly in patients with acute leukemia.
This is a retrospective study of patients diagnosed with proven and probable infection at the University Hospital, Hradec Králové, Czechia between March 2005 and December 2017. Previous cases were identified from the literature and FungiScope database.
Six new cases (5 females, 1 male) of blood-stream infections at the hemato-oncological department were described including epidemiological data of additional 48 patients colonized with the species. Overall, 116 strains of were isolated from different clinical specimens of 54 patients; most of them belonged to the respiratory tract (60.3%). was the most frequent species among arthroconidial yeasts (, , ) recovered from the blood. All our patients with infection had profound neutropenia, a central venous catheter, broad-spectrum antibiotics and antifungal prophylaxis; four had a history of a biliary tract system disease. The diagnosis was based on a positive blood culture in all patients. Four patients died of multiorgan failure and sepsis despite treatment with lipid-based amphotericin B and/or voriconazole. From the literature and FungiScope database, 67 previous cases of infections were evaluated in context of our cases.
infection represents a life-threatening mycosis in severely immunocompromised patients. The successful outcome of treatment seems to be critically dependent on the early diagnosis and the recovery of underlying conditions associated with immune dysfunction or deficiency.
（以前称为 ，现在提议称为 ）是一种丝状酵母样真菌，最近被描述为主要在急性白血病患者中出现的新兴病原体。
这是一项对2005年3月至2017年12月期间在捷克赫拉德茨克拉洛韦大学医院被诊断为确诊和疑似 感染患者的回顾性研究。从文献和真菌监测数据库中识别先前的病例。
描述了血液肿瘤科6例新的血流 感染病例（5例女性，1例男性），包括另外48例定植该菌种患者的流行病学数据。总体而言，从54例患者的不同临床标本中分离出116株 ；其中大多数来自呼吸道（60.3%）。 是从血液中分离出的节孢子酵母（ 、 、 ）中最常见的菌种。所有我们的 感染患者均有严重的中性粒细胞减少、中心静脉导管、广谱抗生素和抗真菌预防用药；4例有胆道系统疾病史。所有患者的诊断均基于血培养阳性。尽管接受了基于脂质体的两性霉素B和/或伏立康唑治疗，仍有4例患者死于多器官功能衰竭和败血症。结合我们的病例对文献和真菌监测数据库中67例先前的 感染病例进行了评估。
感染在严重免疫功能低下的患者中是一种危及生命的真菌病。治疗的成功结果似乎严重依赖于早期诊断以及与免疫功能障碍或缺陷相关的基础疾病的恢复。
