Leoni Massimiliano, Riccardi Niccolò, Rotulo Gioacchino Andrea, Godano Elisabetta, Faraci Maura, Bandettini Roberto, Esposto Maria Carmela, Castagnola Elio
Hematopoietic Stem Cell Transplantation Unit, IRCCS G Gaslini, via Gaslini 5, 16147 Genova, Italy.
Clinic of Infectious Diseases, Policlinico San Martino Hospital, University of Genoa, Largo Rosanna Benzi 10, 16132 Genova, Italy.
Med Mycol Case Rep. 2018 Dec 21;23:65-67. doi: 10.1016/j.mmcr.2018.12.005. eCollection 2019 Mar.
is an ascomycetous fungus causing invasive disease in immuno-compromised patients. Neutropenia, contaminated venous catheters, previous antifungal treatment are risk factors for this infection. We report a case of fungemia with pulmonary, renal and skin localizations in a 6-year-old boy with prolonged neutropenia because of three allogeneic hematopoietic stem cell transplantations. The infection was controlled by aggressive and strictly monitored combination therapy with voriconazole and liposomial-ampthotericine-B along with durable recover from neutropenia.
是一种在免疫功能低下患者中引起侵袭性疾病的子囊菌。中性粒细胞减少、静脉导管污染、先前的抗真菌治疗是这种感染的危险因素。我们报告一例6岁男孩因三次异基因造血干细胞移植导致长期中性粒细胞减少，发生了伴有肺部、肾脏和皮肤定位的真菌血症。通过伏立康唑和脂质体两性霉素B的积极且严格监测的联合治疗以及中性粒细胞减少的持久恢复，感染得到了控制。
