Kang Yongbo, Cai Yue, Zhao Yanqin, Yang Ying
Department of Endocrinology, Affiliated Hospital of Yunnan University, Kunming, China.
Department of Microbiology and Immunology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, China.
Front Nutr. 2022 Sep 15;9:979876. doi: 10.3389/fnut.2022.979876. eCollection 2022.
Alopecia areata (AA) accounts for the autoimmune disorder mediated by T cells, whose prognostic outcome cannot be predicted and curative treatment is unavailable at present. The AA pathogenic mechanism remains largely unclear, even though follicular attack has been suggested to result from that attack of immune privilege-losing hair follicles driven by immunity. Recently, gut microbiota is suggested to have an important effect on immunoregulation under autoimmune situations like AA. Fecal microbial transplantation (FMT) may be used to treat AA. Nonetheless, related research remains at the initial stage. To promote the rapid progress of relevant research, the present work aimed to shed more lights on gut microbiota's effect on AA, early diagnostic biomarker and FMT therapeutics.
斑秃（AA）是一种由T细胞介导的自身免疫性疾病，其预后无法预测，目前也没有治愈方法。尽管有研究表明，毛囊攻击是由免疫驱动的免疫特权丧失毛囊攻击引起的，但AA的致病机制仍不清楚。最近的研究表明，肠道微生物群在AA等自身免疫情况下对免疫调节有重要影响。粪便微生物移植（FMT）可能用于治疗AA。然而，相关研究仍处于初期阶段。为了促进相关研究的快速进展，本研究旨在进一步阐明肠道微生物群对AA的影响、早期诊断生物标志物和FMT治疗方法。
