Wu Mingyang, Chen Xingyu, Lu Qianjin, Yao Xu
Department of Allergy and Rheumatology, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China.
Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Heliyon. 2024 Sep 7;10(18):e37432. doi: 10.1016/j.heliyon.2024.e37432. eCollection 2024 Sep 30.
The regulation of immune functions and the maintenance of homeostasis in the internal environment are both integral to human gut microbiota (GM). If GM is disturbed, it can result in a range of autoimmune diseases, including chronic inflammatory skin conditions. Chronic inflammatory skin diseases driven by T or B-cell-mediated immune reactions are complex, including the most prevalent diseases and some rare diseases. Expanding knowledge of GM dysbiosis in chronic inflammatory skin diseases has emerged. The GM has some causal roles in the pathogenesis of these skin conditions. Targeting microbiota treatment, particularly fecal microbiota transplantation (FMT), is considered to be a promising strategy. FMT was commonly used in intestinal diseases by reshaping and balancing GM, serving as a reasonable administration in these skin inflammatory diseases. This paper summarizes the existing knowledge of GM dysbiosis in chronic inflammatory skin diseases and the research data on FMT treatment for such conditions.
人类肠道微生物群（GM）对于免疫功能的调节以及内环境稳态的维持均至关重要。如果GM受到干扰，可能会导致一系列自身免疫性疾病，包括慢性炎症性皮肤病。由T或B细胞介导的免疫反应驱动的慢性炎症性皮肤病很复杂，包括最常见的疾病和一些罕见疾病。关于慢性炎症性皮肤病中GM失调的认识正在不断扩展。GM在这些皮肤病的发病机制中具有一些因果作用。针对微生物群的治疗，特别是粪便微生物群移植（FMT），被认为是一种有前景的策略。FMT通过重塑和平衡GM，常用于肠道疾病，在这些皮肤炎症性疾病中也是一种合理的治疗方法。本文总结了慢性炎症性皮肤病中GM失调的现有知识以及FMT治疗此类疾病的研究数据。
