Chhabra Pratyaksh, Ingole Nishikant
Medicine and Surgery, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, IND.
Pharmacology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, IND.
Cureus. 2022 Aug 29;14(8):e28563. doi: 10.7759/cureus.28563. eCollection 2022 Aug.
Millions of people worldwide are affected by the prevalent clinical issue, gastroesophageal reflux disease (GERD). Both conventional and unusual symptoms can identify patients. Many people with GERD benefit from symptomatic relief and are shielded from consequences by acid suppression medication. Our capacity to recognise and manage disease consequences has improved thanks to developments in diagnostic and therapeutic technologies. One of the biggest typical gastrointestinal problems treated by physicians and primary care doctors is GERD, which is characterised by heartburn and regurgitation symptoms. GERD prevalence has increased, especially in North America and East Asia. Proton pump inhibitors (PPIs) have been the cornerstone of medical treatment for GERD for the past thirty years. However, clinicians and patients are becoming more aware of the adverse effects of the PPI class of medications recently. Additionally, surgical fundoplication has significantly decreased, while the evolution of non-medical therapeutic methodologies for GERD has increased. In the treatment of GERD, lifestyle changes are crucial. Individual variances can be seen in how GERD symptoms change in response to different diets. The study implies that there may be a connection between reflux occurrence and salty foods, chocolates, fat-rich foods, and aerated beverages, even if there is insufficient data to support this theory. In lifestyle modifications, other factors involved are the head of the bed, patients' lying down position, smoking, fat or obesity, and physical exercise. The number of reviews focusing on various diagnostic techniques and treatment modalities is very less, so this review puts emphasis on these areas. This review also covers GERD and its symptoms, epidemiology, and pathophysiology, but significantly focuses on diagnosis, treatment, and lifestyle modification effects.
全球数百万人受到常见临床问题——胃食管反流病(GERD)的影响。患者可通过传统症状和非典型症状得以确诊。许多GERD患者的症状得到缓解,并通过抑酸药物预防了并发症。诊断和治疗技术的发展提高了我们识别和处理疾病并发症的能力。GERD是内科医生和初级保健医生治疗的最常见胃肠道问题之一,其特征为烧心和反流症状。GERD的患病率有所上升,尤其是在北美和东亚地区。在过去三十年中,质子泵抑制剂(PPI)一直是GERD药物治疗的基石。然而,临床医生和患者最近越来越意识到PPI类药物的不良反应。此外,外科胃底折叠术显著减少,而GERD非药物治疗方法的发展有所增加。在GERD的治疗中,生活方式的改变至关重要。GERD症状对不同饮食的反应存在个体差异。该研究表明,尽管缺乏足够的数据支持这一理论,但反流的发生可能与咸味食物、巧克力、高脂肪食物和充气饮料之间存在关联。在生活方式改变方面,其他相关因素包括床头高度、患者的卧位、吸烟、肥胖或超重以及体育锻炼。专注于各种诊断技术和治疗方式的综述数量非常少,因此本综述着重于这些领域。本综述还涵盖了GERD及其症状、流行病学和病理生理学,但重点显著放在诊断、治疗和生活方式改变的影响上。