Zarei Hatam, Tamri Pari, Asl Sara Soleimani, Soleimani Meysam, Moradkhani Shirin
Department of Pharmacology & Toxicology, School of Pharmacy, Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Anatomical Sciences, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
J Pharmacopuncture. 2022 Sep 30;25(3):258-267. doi: 10.3831/KPI.2022.25.3.258.
OBJECTIVES: Hypertrophic scars (HSs) are caused by abnormal wound healing. To date, no standard treatment has been made available for HSs. has been reported to accelerate wound healing and has the potential to prevent HS formation. In this study, we investigated the anti-scarring effects of extract (SSE) in a rabbit ear model of scarring. METHODS: In this study, New Zealand white rabbit (weight 2.3-2.5 kg) were used. In the prevention phase of the study, three test groups received 5%, 10%, and 15% ointments of SSE in the Eucerin base, the fourth group received Eucerin, and the fifth group received no treatment. The samples were obtained on day 35 after wounding. In the treatment phase of the study, the test groups received an intralesional injection of SSE (5%, 10%, and 15%), the fourth group received an intralesional injection of triamcinolone, the fifth group received a solvent (injection vehicle), and the sixth group received no treatment. To evaluate the anti-scarring effects of SSE, the scar elevation index (SEI), epidermis thickness index (ETI), collagen deposition, and MMP2 and MMP9 gene expression were evaluated. RESULTS: A significant reduction in SEI, ETI, and collagen deposition was noted in animals treated with SSE compared with the control groups. In addition, topical SSE stimulated MMP2 and MMP9 gene expression. CONCLUSION: The findings of this study demonstrate the potential for SSE in the prevention and treatment of HS. SSE could be prepared as an appropriate formulation to treat wounds and prevent abnormal scarring.
目的：肥厚性瘢痕（HSs）由异常伤口愈合引起。迄今为止，尚无针对HSs的标准治疗方法。据报道，[具体物质未提及]可加速伤口愈合并有可能预防HS形成。在本研究中，我们在兔耳瘢痕模型中研究了[具体提取物未提及]提取物（SSE）的抗瘢痕作用。 方法：本研究使用新西兰白兔（体重2.3 - 2.5千克）。在研究的预防阶段，三个试验组分别接受含5%、10%和15% SSE的优色林基质软膏，第四组接受优色林，第五组不进行治疗。在受伤后第35天获取样本。在研究的治疗阶段中，试验组接受病灶内注射SSE（5%、10%和15%），第四组接受病灶内注射曲安奈德，第五组接受溶剂（注射载体），第六组不进行治疗。为评估SSE的抗瘢痕作用，对瘢痕隆起指数（SEI）、表皮厚度指数（ETI）、胶原沉积以及MMP2和MMP9基因表达进行了评估。 结果：与对照组相比，用SSE治疗的动物的SEI、ETI和胶原沉积显著降低。此外，局部应用SSE刺激了MMP2和MMP9基因表达。 结论：本研究结果证明了SSE在预防和治疗HS方面的潜力。SSE可以制备成合适的制剂用于治疗伤口和预防异常瘢痕形成。
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