Deng Zijian, Xu Xiangkun, Iordachita Iulian, Dehghani Hamid, Zhang Bin, Wong John W, Wang Ken Kang-Hsin
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland 21287, USA.
Biomedical Imaging and Radiation Technology Laboratory (BIRTLab), Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Biomed Opt Express. 2022 Aug 30;13(9):4970-4989. doi: 10.1364/BOE.460737. eCollection 2022 Sep 1.
Due to low imaging contrast, a widely-used cone-beam computed tomography-guided small animal irradiator is less adept at localizing soft tissue targets. Bioluminescence tomography (BLT), which combines a model of light propagation through tissue with an optimization algorithm, can recover a spatially resolved tomographic volume for an internal bioluminescent source. We built a novel mobile BLT system for a small animal irradiator to localize soft tissue targets for radiation guidance. In this study, we elaborate its configuration and features that are indispensable for accurate image guidance. Phantom and validations show the BLT system can localize targets with accuracy within 1 mm. With the optimal choice of threshold and margin for target volume, BLT can provide a distinctive opportunity for investigators to perform conformal biology-guided irradiation to malignancy.
由于成像对比度低，一种广泛使用的锥束计算机断层扫描引导的小动物辐照器在定位软组织目标方面不太擅长。生物发光断层扫描（BLT）将光在组织中传播的模型与优化算法相结合，可以为内部生物发光源恢复空间分辨的断层体积。我们为小动物辐照器构建了一种新型移动BLT系统，用于定位软组织目标以进行放射引导。在本研究中，我们阐述了其配置和准确图像引导所必需的特征。体模和验证表明，BLT系统能够以1毫米以内的精度定位目标。通过对目标体积的阈值和边界进行最佳选择，BLT可以为研究人员提供一个独特的机会，对恶性肿瘤进行适形生物引导照射。
