Kim Gwon-Min, Song Seunghwan, Park Jong-Hwan, Tak Young Jin, Wang Il Jae, Huh Up, Cho Jeong Su
Department of Medical Research Institute, Pusan National University, Busan, South Korea.
Department of Thoracic and Cardiovascular Surgery, Pusan National University School of Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea.
Front Physiol. 2022 Sep 16;13:973265. doi: 10.3389/fphys.2022.973265. eCollection 2022.
This study aimed to determine the relationship between sarcopenia and physical function, and the best method of diagnosing sarcopenia in healthy adults. Early prevention of sarcopenia is important; however, no studies have been conducted in healthy and relatively young adults. In addition, it remains unclear whether calf circumference is associated with sarcopenia-defined variables. A total of 85 healthy male participants were enrolled, and the mean standard deviation age of the participants was 59.76 (8.12) years. Abdominal computed tomography (CT) was performed to measure muscle areas. All subjects were divided into sarcopenia and non-sarcopenia groups based on skeletal muscle mass index using computed tomography. Sarcopenia showed a tendency to be related to lower grip strength, five times sit-to-stand and timed up and go tests for physical function. This result shows that overweight and obesity in the sarcopenia group had fully adjusted odds ratios of 0.026 (95% CI: 0.002-0.317) and 0.008 (95% CI: 0.001-0.096), respectively. Calf circumference was higher specificity (71.43 and 64.86) better than bioelectrical impedance analysis-based skeletal mass index and had a similar sensitivity (72.09 and 82.35). In conclusion, calf circumference suggests the need to consider its use as a tool for assessing muscle mass in the diagnosis of sarcopenia.
本研究旨在确定肌肉减少症与身体功能之间的关系，以及在健康成年人中诊断肌肉减少症的最佳方法。早期预防肌肉减少症很重要；然而，尚未对健康且相对年轻的成年人进行过相关研究。此外，小腿围度是否与肌肉减少症定义的变量相关仍不清楚。总共招募了85名健康男性参与者，参与者的平均标准差年龄为59.76（8.12）岁。进行腹部计算机断层扫描（CT）以测量肌肉面积。所有受试者根据使用计算机断层扫描得出的骨骼肌质量指数分为肌肉减少症组和非肌肉减少症组。肌肉减少症与较低的握力、五次坐立试验以及计时起立行走身体功能测试呈相关趋势。该结果表明，肌肉减少症组中的超重和肥胖者经充分调整后的优势比分别为0.026（95%置信区间：0.002 - 0.317）和0.008（95%置信区间：0.001 - 0.096）。小腿围度比基于生物电阻抗分析的骨骼肌质量指数具有更高的特异性（分别为71.43和64.86），且敏感性相似（分别为72.09和82.35）。总之，小腿围度表明有必要考虑将其用作评估肌肉减少症诊断中肌肉质量的工具。
