Wang Xu-Hua, Xu Ding-Qiao, Chen Yan-Yan, Yue Shi-Jun, Fu Rui-Jia, Huang Lu, Tang Yu-Ping
Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, Shaanxi University of Chinese Medicine, Xi'an, China.
Front Pharmacol. 2022 Sep 16;13:952938. doi: 10.3389/fphar.2022.952938. eCollection 2022.
Sepsis is described as a dysregulation of the immune response to infection, which leads to life-threatening organ dysfunction. The interaction between intestinal microbiota and sepsis can't be ignored. Furthermore, the intestinal microbiota may regulate the progress of sepsis and attenuate organ damage. Thus, maintaining or restoring microbiota may be a new way to treat sepsis. Traditional Chinese medicine (TCM) assumes a significant part in the treatment of sepsis through multi-component, multi-pathway, and multi-targeting abilities. Moreover, TCM can prevent the progress of sepsis and improve the prognosis of patients with sepsis by improving the imbalance of intestinal microbiota, improving immunity and reducing the damage to the intestinal barrier. This paper expounds the interaction between intestinal microbiota and sepsis, then reviews the current research on the treatment of sepsis with TCM, to provide a theoretical basis for its clinical application.
脓毒症被描述为对感染的免疫反应失调，可导致危及生命的器官功能障碍。肠道微生物群与脓毒症之间的相互作用不容忽视。此外，肠道微生物群可能调节脓毒症的进展并减轻器官损伤。因此，维持或恢复微生物群可能是治疗脓毒症的一种新方法。中药通过多成分、多途径和多靶点的能力在脓毒症治疗中发挥重要作用。此外，中药可通过改善肠道微生物群失衡、提高免疫力和减少对肠道屏障的损伤来预防脓毒症的进展并改善脓毒症患者的预后。本文阐述了肠道微生物群与脓毒症之间的相互作用，进而综述了目前中药治疗脓毒症的研究，为其临床应用提供理论依据。
