Chen De-Ta, Rao Wu, Shen Xue, Chen Lin, Wan Zi-Jian, Sheng Xiao-Ping, Fan Tian-You
Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Pharmacol. 2022 Sep 15;13:981048. doi: 10.3389/fphar.2022.981048. eCollection 2022.
Higenamine (HG) is a chemical compound found in various plants, such as aconite. Recent pharmacological studies have demonstrated its effectiveness in the management of many diseases. Several mechanisms of action of HG have been proposed; however, they have not yet been classified. This review summarises the signalling pathways and pharmacological targets of HG, focusing on its potential as a naturally extracted drug. Articles related to the pharmacological effects, signalling pathways and pharmacological targets of HG were selected by searching the keyword "Higenamine" in the PubMed, Web of Science and Google Scholar databases without limiting the search by publication years. HG possesses anti-oxidant, anti-apoptotic, anti-inflammatory, electrophysiology regulatory, anti-fibrotic and lipid-lowering activities. It is a structural analogue of catecholamines and possesses characteristics similar to those of adrenergic receptor ligands. It can modulate multiple targets, including anti-inflammation- and anti-apoptosis-related targets and some transcription factors, which directly or indirectly influence the disease course. Other naturally occurring compounds, such as cucurbitacin B (Cu B) and 6-gingerol (6-GR), can be combined with HG to enhance its anti-apoptotic activity. Although significant research progress has been made, follow-up pharmacological studies are required to determine the exact mechanism of action, new signalling pathways and targets of HG and the effects of using it in combination with other drugs.
去甲乌药碱（HG）是一种存在于多种植物中的化合物，如乌头。近期的药理学研究已证明其在多种疾病治疗中的有效性。关于HG的几种作用机制已被提出；然而，它们尚未被分类。本综述总结了HG的信号通路和药理学靶点，重点关注其作为天然提取物药物的潜力。通过在PubMed、科学网和谷歌学术数据库中搜索关键词“去甲乌药碱”来选择与HG的药理作用、信号通路和药理学靶点相关的文章，搜索不限制发表年份。HG具有抗氧化、抗凋亡、抗炎、电生理调节、抗纤维化和降脂活性。它是儿茶酚胺的结构类似物，具有与肾上腺素能受体配体相似的特性。它可以调节多个靶点，包括与抗炎和抗凋亡相关的靶点以及一些转录因子，这些靶点直接或间接影响疾病进程。其他天然存在的化合物，如葫芦素B（Cu B）和6-姜酚（6-GR），可以与HG联合使用以增强其抗凋亡活性。尽管已取得显著的研究进展，但仍需要后续的药理学研究来确定HG的确切作用机制、新的信号通路和靶点以及与其他药物联合使用的效果。
