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心血管疾病中外泌体长链非编码RNA的新进展

New Developments in Exosomal lncRNAs in Cardiovascular Diseases.

作者信息

Yuan Zhu, Huang Weiqiang

机构信息

Department of Geriatric Cardiology, Guangxi Key Laboratory Base of Precision Medicine in Cardio-Cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-Cerebrovascular Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

出版信息

Front Cardiovasc Med. 2021 Jul 8;8:709169. doi: 10.3389/fcvm.2021.709169. eCollection 2021.

DOI:10.3389/fcvm.2021.709169
PMID:34307511
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8295603/
Abstract

Long non-coding RNAs (lncRNAs) are non-coding RNAs with lengths >200 nt and are involved in the occurrence and development of cardiovascular diseases (CVDs). Exosomes are secreted and produced by various cell types. Exosome contents include various ncRNAs, proteins and lipids. Exosomes are also important mediators of intercellular communication. The proportion of lncRNAs in exosomes is low, but increasing evidence suggests that exosomal lncRNAs play important roles in CVDs. We focused on research progress in exosomal lncRNAs in atherosclerosis, myocardial infarction, myocardial ischemia-reperfusion injury, cardiac angiogenesis, cardiac aging, rheumatic heart disease, and chronic kidney disease combined with CVD. The potential diagnostic and therapeutic effects of exosomal lncRNAs in CVDs are summarized based on preclinical studies involving animal and cell models and circulating exosomes in clinical patients. Finally, the challenges and possible prospects of exosomes and exosomal lncRNAs in clinical applications related to CVD are discussed.

摘要

长链非编码RNA（lncRNAs）是长度大于200个核苷酸的非编码RNA，参与心血管疾病（CVDs）的发生和发展。外泌体由多种细胞类型分泌产生。外泌体内容物包括各种非编码RNA、蛋白质和脂质。外泌体也是细胞间通讯的重要介质。lncRNAs在外泌体中的比例较低，但越来越多的证据表明，外泌体lncRNAs在CVDs中发挥重要作用。我们重点关注了外泌体lncRNAs在动脉粥样硬化、心肌梗死、心肌缺血-再灌注损伤、心脏血管生成、心脏衰老、风湿性心脏病以及合并CVD的慢性肾脏病中的研究进展。基于涉及动物和细胞模型的临床前研究以及临床患者的循环外泌体，总结了外泌体lncRNAs在CVDs中的潜在诊断和治疗作用。最后，讨论了外泌体和外泌体lncRNAs在与CVD相关的临床应用中的挑战和可能的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce66/8295603/5fee4b3c6568/fcvm-08-709169-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce66/8295603/bb9394c6453b/fcvm-08-709169-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce66/8295603/99ed338d6fa9/fcvm-08-709169-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce66/8295603/5fee4b3c6568/fcvm-08-709169-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce66/8295603/bb9394c6453b/fcvm-08-709169-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce66/8295603/99ed338d6fa9/fcvm-08-709169-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce66/8295603/5fee4b3c6568/fcvm-08-709169-g0003.jpg

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[1]
New Developments in Exosomal lncRNAs in Cardiovascular Diseases.

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[4]
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[9]
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[3]
Upregulation of LncRNA UCA1 promotes cardiomyocyte proliferation by inhibiting the miR-128/SUZ12/P27 pathway.

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[5]
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Extracell Vesicle. 2023-12

[6]
LIPCAR levels in plasma-derived extracellular vesicles is associated with left ventricle remodeling post-myocardial infarction.

J Transl Med. 2024-1-6

[7]
Exosomes and their derivatives as biomarkers and therapeutic delivery agents for cardiovascular diseases: Situations and challenges.

J Transl Int Med. 2023-12-20

[8]
Propofol inhibits myocardial injury induced by microvesicles derived from hypoxia-reoxygenated endothelial cells via lncCCT4-2/CCT4 signaling.

Biol Res. 2023-5-5

[9]
The Potential Roles of Exosomes Carrying APP and Tau Cleavage Products in Alzheimer's Disease.

J Clin Med. 2023-2-27

[10]
Comparative Analysis of Non-Coding RNA Transcriptomics in Heart Failure.

Biomedicines. 2022-11-30

本文引用的文献

[1]
Potential of exosomes as diagnostic biomarkers and therapeutic carriers for doxorubicin-induced cardiotoxicity.

Int J Biol Sci. 2021

[2]
The Molecular Mechanisms of Cardiotoxicity Induced by HER2, VEGF, and Tyrosine Kinase Inhibitors: an Updated Review.

Cardiovasc Drugs Ther. 2022-6

[3]
Exosomes-Mediated LncRNA ZEB1-AS1 Facilitates Cell Injuries by miR-590-5p/ETS1 Axis Through the TGF-β/Smad Pathway in Oxidized Low-density Lipoprotein-induced Human Umbilical Vein Endothelial Cells.

J Cardiovasc Pharmacol. 2021-4-1

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Mol Ther Nucleic Acids. 2021-2-10

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The Role of Exosomes and Exosomal MicroRNA in Cardiovascular Disease.

Front Cell Dev Biol. 2021-1-12

[10]
Exosomes Released from CaSR-Stimulated PMNs Reduce Ischaemia/Reperfusion Injury.

Oxid Med Cell Longev. 2021

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