Jiang Feng, Li Xin-Xin, Xie Zhi-Yang, Liu Lei, Wu Xiao-Tao, Wang Yun-Tao
Southeast University Medical College, Nanjing, Jiangsu, China.
Department of Spine Surgery, Southeast University ZhongDa Hospital, Nanjing, Jiangsu, China.
World Neurosurg. 2023 Nov;179:e601-e613. doi: 10.1016/j.wneu.2023.09.024. Epub 2023 Sep 13.
To analyze the current research trends and potential mechanisms related to the role of autophagy in intervertebral disc degeneration (IVDD) and to provide new ideas for future research in this field.
All articles on IVDD and autophagy were retrieved and extracted from the Web of Science (WoS) core collection database. The results were evaluated and visualized using the bibliometric Web site, CiteSpace, and VOSviewer software, including annual articles published, countries, institutions, authors, journals, research areas, funding agencies, citations, and keywords.
From January 1, 2011, to December 31, 2022, 323 reviews and original articles were included, and the overall trend in the number of articles was increasing rapidly. China and the United States were the countries with the most scientific research achievements. The 323 articles received a total number of citations of 6949, with an H index of 43 and an average citation of 21.51. The top publication country, institution, author, journal, research area, and funding agency were China, Huazhong University of Science and Technology, Cao Yang of Tongji Medical College, Oxidative Medicine and Cellular Longevity, cell biology, and National Natural Science Foundation of China, respectively. Most of the keywords were associated with the mechanisms and regulatory networks of autophagy. In addition, with increasing evidence showing the key role of autophagy in IVDD, therapy, signaling pathway, and mitophagy are emerging as new research hot spots that should be paid more attention.
This study provided a scientific perspective on autophagy in IVDD and elucidated the current research status and hot spots in this field. The mechanism of autophagy and the application of regulating autophagy in the treatment of IVDD deserve further research.
分析自噬在椎间盘退变（IVDD）中的作用的当前研究趋势和潜在机制，为该领域的未来研究提供新思路。
从Web of Science（WoS）核心合集数据库中检索并提取所有关于IVDD和自噬的文章。使用文献计量网站CiteSpace和VOSviewer软件对结果进行评估和可视化，包括发表的年度文章、国家、机构、作者、期刊、研究领域、资助机构、引用次数和关键词。
2011年1月1日至2022年12月31日，共纳入323篇综述和原创文章，文章数量总体呈快速增长趋势。中国和美国是科研成果最多的国家。这323篇文章的总被引次数为6949次，H指数为43，平均被引次数为21.51。发表文章最多的国家、机构、作者、期刊、研究领域和资助机构分别是中国、华中科技大学、同济医学院的曹阳、《氧化医学与细胞长寿》、细胞生物学和中国国家自然科学基金。大多数关键词与自噬的机制和调控网络相关。此外，随着越来越多的证据表明自噬在IVDD中的关键作用，治疗、信号通路和线粒体自噬正成为新的研究热点，应予以更多关注。
本研究为IVDD中自噬的研究提供了科学视角，阐明了该领域的当前研究现状和热点。自噬机制以及调节自噬在IVDD治疗中的应用值得进一步研究。
