Vassiliu Panteleimon, Patoulis Filippos, Naar Leon, Dendias Georgios, Arkadopoulos Nikolaos
4th Department of Surgery, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Front Rehabil Sci. 2021 Jul 27;2:655400. doi: 10.3389/fresc.2021.655400. eCollection 2021.
Sacral-Nerve-Neuromodulation (SNM) is an effective treatment increasingly used in patients with urinary (UI) and fecal incontinence (FI). The way it acts in the body at its full potential have not yet been elucidated. The authors review the literature on SNM and the way it possibly works, relating it to a case with an unusually favorable outcome. A female presented with UI and FI. Operated for meningocele as a neonate. It the age of 5 bilateral Cohen ureter reimplantation performed for persistent urinary infections due to vesicourethral reflux. At the age of 13, she started complaining about UI associated with a hyper functional detrusor muscle. After a diary incontinence evaluation with a standardized questionnaire, SNM was applied at the age of 18 and was retained for 4 years. She was re-evaluated with a yearly follow-up. The patient retained the positive effect of SNM even after its removal and in addition showed signs of improvement. The patient developed the sensation of fillingness of the bladder and the rectum, which she never had before the SNM implantation, sensation which she retained 29 months after (last follow-up) device removal, allowing her to control her voids. The modern literature hypothesis that SNM contributes to the plasticity of the nerves through the stimulated area is supported by the present case, in which the SNM effect remained and led to improvements even after its removal. Device settings are presented as they may correlate with the result. This reinforces and expands the frontiers of SNM application and research.
骶神经调节(SNM)是一种越来越多地用于治疗尿失禁(UI)和大便失禁(FI)患者的有效疗法。其在体内充分发挥作用的方式尚未阐明。作者回顾了关于SNM及其可能作用方式的文献,并将其与一例预后异常良好的病例相关联。一名女性患者出现尿失禁和大便失禁。新生儿期因脑脊膜膨出接受手术。5岁时,因膀胱输尿管反流导致持续性尿路感染,进行了双侧科恩输尿管再植术。13岁时,她开始抱怨与逼尿肌功能亢进相关的尿失禁。通过标准化问卷进行尿失禁日记评估后,18岁时应用了SNM,并保留了4年。每年进行随访重新评估。即使在移除SNM后,患者仍保留其积极效果,并且还表现出改善迹象。患者出现了膀胱和直肠充盈感,这是SNM植入前从未有过的感觉,在移除装置29个月后(最后一次随访)她仍保留这种感觉,从而能够控制排尿。现代文献提出的SNM通过刺激区域促进神经可塑性的假说在本病例中得到了支持,在该病例中,即使在移除SNM后,其效果仍然存在并导致了改善。文中展示了可能与结果相关的设备设置。这加强并拓展了SNM应用和研究的前沿领域。