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一名9岁膝关节骨髓炎患儿的二水焦磷酸钙晶体：病例报告

Calcium pyrophosphate dihydrate crystals in a 9-year-old with osteomyelitis of the knee: A case report.

作者信息

Pavlis William, Constantinescu David S, Murgai Rajan, Barnhill Spencer, Black Brian

机构信息

Department of Orthopaedics, University of Miami, Miami, 33136, United States.

出版信息

World J Orthop. 2022 Sep 18;13(9):870-875. doi: 10.5312/wjo.v13.i9.870.

DOI:10.5312/wjo.v13.i9.870
PMID:36189334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9516619/
Abstract

BACKGROUND

Calcium pyrophosphate dihydrate deposition disease (CPPD), or pseudogout, is an inflammatory arthritis common among elderly patients, but rarely seen in patients under the age of 40. In the rare cases presented of young patients with CPPD, genetic predisposition or related metabolic conditions were almost always identified.

CASE SUMMARY

The authors report the case of a 9-year-old boy with no past medical history who presented with acute knee pain and swelling after a cat scratch injury 5 d prior. Synovial fluid analysis identified calcium pyrophosphate dihydrate crystals. Further MRI analysis identified osteomyelitis and a small soft tissue abscess.

CONCLUSION

This case presents the extremely rare diagnostic finding of calcium pyrophosphate dihydrate crystals in a previously healthy pediatric patient. The presence of osteomyelitis presents a unique insight into the pathogenesis of these crystals in pediatric patients. More research needs to be done on the role of CPPD in pediatric arthritis and joint infection.

摘要

背景

二水焦磷酸钙沉积病（CPPD），即假性痛风，是一种在老年患者中常见的炎性关节炎，但在40岁以下患者中很少见。在少数报道的年轻CPPD患者病例中，几乎总能发现遗传易感性或相关代谢状况。

病例摘要

作者报告了一例9岁男孩的病例，该男孩既往无病史，在5天前被猫抓伤后出现急性膝关节疼痛和肿胀。滑液分析发现了二水焦磷酸钙晶体。进一步的MRI分析发现了骨髓炎和一个小的软组织脓肿。

结论

该病例呈现了在一名此前健康的儿科患者中极其罕见的二水焦磷酸钙晶体诊断结果。骨髓炎的存在为儿科患者中这些晶体的发病机制提供了独特的见解。关于CPPD在儿科关节炎和关节感染中的作用，还需要进行更多研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cebd/9516619/cffd153144a9/WJO-13-870-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cebd/9516619/729d0b49a304/WJO-13-870-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cebd/9516619/cffd153144a9/WJO-13-870-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cebd/9516619/729d0b49a304/WJO-13-870-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cebd/9516619/cffd153144a9/WJO-13-870-g002.jpg

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