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接种 SARS-CoV-2 疫苗后罕见的皮质盲病例。

A rare case of cortical blindness following vaccination against SARS-CoV-2.

机构信息

Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India.

出版信息

Indian J Ophthalmol. 2022 Oct;70(10):3721-3723. doi: 10.4103/ijo.IJO_1619_22.

DOI:10.4103/ijo.IJO_1619_22
PMID:36190083
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9789863/
Abstract

A 61-year-old male presented with sudden loss of vision in both the eyes about 8 days after the first shot of coronavirus disease 2019 (COVID-19) vaccine (Covishield). On examination, the visual acuity was no perception of light in both the eyes. Contrast-enhanced magnetic resonance imaging (MRI) with diffusion-weighted imaging showed acute cerebral infarcts involving bilateral parieto-occipital region. Considering the temporal correlation with the vaccine shot and absence of any other precipitating factor, we hypothesized that this was probably an immunologic response to the vaccine.

摘要

一位 61 岁男性在接种第一剂 2019 冠状病毒病(COVID-19)疫苗(Covishield)后约 8 天出现双眼突发性视力丧失。检查时,双眼视力均无光感。对比增强磁共振成像(MRI)弥散加权成像显示双侧顶枕叶急性脑梗死。鉴于与疫苗接种的时间相关性以及没有其他诱发因素,我们推测这可能是对疫苗的免疫反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/293c/9789863/20227cb72da6/IJO-70-3721-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/293c/9789863/20227cb72da6/IJO-70-3721-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/293c/9789863/20227cb72da6/IJO-70-3721-g001.jpg

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引用本文的文献

1
Comment on: A rare case of cortical blindness following vaccination against SARS-CoV-2.关于《接种 SARS-CoV-2 疫苗后罕见的皮质盲病例》的评论
Indian J Ophthalmol. 2023 Jun;71(6):2617. doi: 10.4103/IJO.IJO_2640_22.

本文引用的文献

1
Transient visual field loss after COVID-19 vaccination: Experienced by ophthalmologist, case report.新冠疫苗接种后短暂性视野缺损:眼科医生的经历,病例报告
Am J Ophthalmol Case Rep. 2021 Dec;24:101212. doi: 10.1016/j.ajoc.2021.101212. Epub 2021 Sep 23.
2
A Rare Case of Superior Ophthalmic Vein Thrombosis and Thrombocytopenia Following ChAdOx1 nCoV-19 Vaccine Against SARS-CoV-2.接种ChAdOx1新冠疫苗(ChAdOx1 nCoV-19)预防新型冠状病毒肺炎(SARS-CoV-2)后发生的罕见眶上静脉血栓形成和血小板减少症病例
Mediterr J Hematol Infect Dis. 2021 Mar 1;13(1):e2021048. doi: 10.4084/MJHID.2021.048. eCollection 2021.
3
Bilateral superior ophthalmic vein thrombosis, ischaemic stroke, and immune thrombocytopenia after ChAdOx1 nCoV-19 vaccination.
ChAdOx1 nCoV-19疫苗接种后双侧眼上静脉血栓形成、缺血性中风和免疫性血小板减少症。
Lancet. 2021 May 1;397(10285):e11. doi: 10.1016/S0140-6736(21)00872-2. Epub 2021 Apr 14.
4
Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination.ChAdOx1新冠疫苗接种后的血栓形成和血小板减少症
N Engl J Med. 2021 Jun 3;384(22):2124-2130. doi: 10.1056/NEJMoa2104882. Epub 2021 Apr 9.
5
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.ChAdOx1 nCoV-19 疫苗(阿斯利康)对 SARS-CoV-2 的安全性和有效性:巴西、南非和英国四项随机对照试验的中期分析。
Lancet. 2021 Jan 9;397(10269):99-111. doi: 10.1016/S0140-6736(20)32661-1. Epub 2020 Dec 8.