School of Chemical Engineering and Technology, Key Laboratory of Systems Bioengineering (Ministry of Education), Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin 300350, P. R. China.
Bioconjug Chem. 2022 Oct 19;33(10):1944-1952. doi: 10.1021/acs.bioconjchem.2c00407. Epub 2022 Oct 3.
In the tumor microenvironment, there exist microorganisms that metabolize anticancer drugs, leading to chemotherapy failure. To solve this problem, herein, we develop antibiotic and anticancer drug co-delivery micelles, termed colistin crosslinked gemcitabine micelle (CCGM). A self-immolative linker enables colistin and gemcitabine to be released on demand without affecting their antibacterial and anticancer effects. Once CCGM is delivered to the tumor microenvironment, intracellular glutathione triggers the release of colistin and gemcitabine, inhibiting the growth of microbes in the tumor, thus eliminating the microbe-induced drug resistance of tumor.
在肿瘤微环境中，存在着代谢抗癌药物的微生物，导致化疗失败。为了解决这个问题，我们开发了一种抗生素和抗癌药物共递送胶束，称为多粘菌素交联吉西他滨胶束（CCGM）。一种自毁性连接剂使多粘菌素和吉西他滨能够按需释放，而不影响它们的抗菌和抗癌作用。一旦 CCGM 递送到肿瘤微环境中，细胞内谷胱甘肽触发多粘菌素和吉西他滨的释放，抑制肿瘤中微生物的生长，从而消除微生物诱导的肿瘤耐药性。
