School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, China.
School of Resources and Environmental Engineering, Wuhan University of Technology, Wuhan, China.
Front Immunol. 2023 Feb 2;14:1084926. doi: 10.3389/fimmu.2023.1084926. eCollection 2023.
Tumor microbiota is a group of microorganisms located in tumor tissues with rich diversity that can promote tumorigenesis and development, and different types of tumors have different tumor microbiotas, which has important implications for tumor research, detection, and clinical treatment. In this review, we examine the diversity of the tumor microbiota, discuss the impact of chemotherapy and immunotherapy on tumor microbiota diversity, and summarize recent advances in the use of genetically engineered bacteria for the treatment of tumors. In addition, we propose key questions that need to be further addressed by the tumor microbiota.
肿瘤微生物群是一组位于肿瘤组织中的微生物，具有丰富的多样性，可促进肿瘤的发生和发展，不同类型的肿瘤具有不同的肿瘤微生物群，这对肿瘤的研究、检测和临床治疗具有重要意义。在这篇综述中，我们研究了肿瘤微生物群的多样性，讨论了化疗和免疫疗法对肿瘤微生物群多样性的影响，并总结了最近利用基因工程细菌治疗肿瘤的进展。此外，我们提出了肿瘤微生物群需要进一步解决的关键问题。
