Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Detroit, MI.
Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI.
J Immunol. 2022 Oct 15;209(8):1450-1464. doi: 10.4049/jimmunol.2200433.
Pregnancy success requires constant dialogue between the mother and developing conceptus. Such crosstalk is facilitated through complex interactions between maternal and fetal cells at distinct tissue sites, collectively termed the "maternal-fetal interface." The emergence of single-cell technologies has enabled a deeper understanding of the unique processes taking place at the maternal-fetal interface as well as the discovery of novel pathways and immune and nonimmune cell types. Single-cell approaches have also been applied to decipher the cellular dynamics throughout pregnancy, in parturition, and in obstetrical syndromes such as recurrent spontaneous abortion, preeclampsia, and preterm labor. Furthermore, single-cell technologies have been used during the recent COVID-19 pandemic to evaluate placental viral cell entry and the impact of SARS-CoV-2 infection on maternal and fetal immunity. In this brief review, we summarize the current knowledge of cellular immunobiology in pregnancy and its complications that has been generated through single-cell investigations of the maternal-fetal interface.
妊娠成功需要母体和发育中的胚胎不断对话。这种交流是通过母体和胎儿细胞在不同组织部位的复杂相互作用来实现的，这些相互作用被统称为“母体-胎儿界面”。单细胞技术的出现使人们能够更深入地了解母体-胎儿界面上发生的独特过程，并发现新的途径以及免疫和非免疫细胞类型。单细胞方法还被应用于破译妊娠、分娩以及复发性自然流产、子痫前期和早产等产科综合征过程中的细胞动态。此外，单细胞技术在最近的 COVID-19 大流行期间被用于评估胎盘病毒细胞进入和 SARS-CoV-2 感染对母体和胎儿免疫的影响。在这篇简短的综述中，我们总结了通过对母体-胎儿界面的单细胞研究得出的有关妊娠及其并发症的细胞免疫生物学的现有知识。
