Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Am J Reprod Immunol. 2022 Dec;88(6):e13631. doi: 10.1111/aji.13631. Epub 2022 Oct 19.
Recurrent spontaneous abortion (RSA) or recurrent pregnancy loss (RPL) is an abnormality that has a great impact on women's quality of life. RSA is defined as at least three unexplained abortions (without prior live birth) occurring before the 20th week of pregnancy.
The present review attempts to discuss immunologic deviations in mouse models of RSA.
The mating of DBA/2J males with CBA/J female mice has provided specialists with a homologous model of RSA. Much of the research using the CBA/J × DBA/2J mouse model has shown immune system alteration results in rejection. The link between RSA and the immune system suggests new approaches to prevent RSA from an immunological perspective. Rejection in this model is linked with the changed immune system during pregnancy, including change in Th1/Th2 ratio and defects in T and NK cells function, and so forth.
The use of animal models prone to RSA can help a lot to solve the remained mysteries. This study reviews the existing knowledge of immune system roles in the RSA mouse models.
复发性自然流产（RSA）或复发性妊娠丢失（RPL）是一种对女性生活质量有重大影响的异常。RSA 定义为至少三次不明原因的流产（无先前活产）发生在怀孕 20 周之前。
本综述试图讨论 RSA 小鼠模型中的免疫偏差。
DBA/2J 雄性与 CBA/J 雌性小鼠的交配为专家提供了 RSA 的同源模型。使用 CBA/J×DBA/2J 小鼠模型进行的大部分研究表明，免疫系统的改变导致排斥。RSA 与免疫系统之间的联系表明，从免疫学角度来看，有新的方法可以预防 RSA。该模型中的排斥与妊娠期间免疫系统的改变有关，包括 Th1/Th2 比例的改变以及 T 和 NK 细胞功能的缺陷等。
使用易发生 RSA 的动物模型可以帮助解决许多遗留的谜团。本研究综述了免疫系统在 RSA 小鼠模型中的作用的现有知识。
