Department of Radiology, Yiyang Central Hospital, Yiyang, Hunan, P. R. China.
Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, P. R. China.
PLoS One. 2024 Oct 10;19(10):e0309088. doi: 10.1371/journal.pone.0309088. eCollection 2024.
The relationship between dysregulation of the immune system and reproductive health, particularly in the context of abortion, is an area of critical research. Identifying the immunological factors that contribute to abortion could provide valuable insights into its prevention and management.
This study used bidirectional two-sample Mendelian Randomization (MR) approach to evaluate the causal link between 731 immune cell features and the risk of abortion. The study analyzed GWAS data from 257,561 Europeans, including 7,069 cases and 250,492 controls, by utilizing genetic variation as instrumental variables. The immune phenotypes included several cell types, including B cells, T cells, TBNK cells, Treg cells, and monocytes. These were analyzed using the 'TwoSampleMR' package in R software.
The study identified 34 immune phenotypes that have a significant causal relationship with abortion risk. Notably, Results from the B cell group showed a positive correlation between abortion and certain phenotypes, including Unsw mem %B cell, PB/PC %B cell, IgD+ CD24+ %B cell and Naive-mature B cell %lymphocyte. In the T cell group, certain maturation stages such as Naive CD8br %T cell and CD4 on CD45RA+ CD4+ exhibited negative causal links, whereas CCR7 on naive CD8br showed a positive association. The group of Treg cells showed both positive and negative causal relationships with abortion, highlighting the complexity of immune regulation in reproductive health.
This study reflects the causal relationship between different subtypes of different immune cells and abortion. The results underscore the importance of the immune system in reproductive health and suggest potential therapeutic interventions targeting these immunological pathways.
免疫系统失调与生殖健康之间的关系，尤其是在流产方面，是一个极具研究价值的领域。确定导致流产的免疫因素可能为其预防和管理提供有价值的见解。
本研究采用双向两样本孟德尔随机化（MR）方法，评估了 731 种免疫细胞特征与流产风险之间的因果关系。该研究通过利用遗传变异作为工具变量，分析了来自 257561 名欧洲人的 GWAS 数据，其中包括 7069 例病例和 250492 例对照。所分析的免疫表型包括几种细胞类型，包括 B 细胞、T 细胞、TBNK 细胞、Treg 细胞和单核细胞。这些数据使用 R 软件中的“TwoSampleMR”包进行分析。
该研究确定了 34 种免疫表型与流产风险有显著的因果关系。值得注意的是，B 细胞组的结果显示，某些表型与流产之间呈正相关，包括 Unsw mem%B 细胞、PB/PC%B 细胞、IgD+CD24+B 细胞和 Naive-mature B 细胞%lymphocyte。在 T 细胞组中，某些成熟阶段，如 Naive CD8br%T 细胞和 CD4 上的 CD45RA+CD4+，表现出负向因果关系，而 Naive CD8br 上的 CCR7 则表现出正向关联。Treg 细胞组表现出与流产的正向和负向因果关系，突显了免疫调节在生殖健康中的复杂性。
本研究反映了不同免疫细胞亚群不同亚型与流产之间的因果关系。研究结果强调了免疫系统在生殖健康中的重要性，并提示了针对这些免疫途径的潜在治疗干预措施。
