Pattnaik Satyanarayan, Swain Kalpana, Ramakrishna Seeram
Division of Advanced Drug Delivery, Talla Padmavathi College of Pharmacy, Warangal, India.
NUS Center for Nanofibers and Nanotechnology, Department of Mechanical Engineering, National University of Singapore, Singapore, Singapore.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2023 Mar;15(2):e1859. doi: 10.1002/wnan.1859. Epub 2022 Oct 4.
Poor aqueous solubility of both, existing drug molecules and those which are currently in the developmental stage, have posed a great challenge to pharmaceutical scientists because they often exhibit poor dissolution behavior and subsequent poor and erratic bioavailability. This has triggered extensive research to explore nanotechnology-based technology platforms for possible rescue. Recently, nanofibers have been exploited widely for diverse biomedical applications including for drug delivery. Electrospun nanofibers are capable of preserving the homogeneously loaded therapeutic agents in amorphous state potentialy impairing devitrification. The present review aims at providing an overview of the various key factors that affect the electrospinning process and characteristics of the nanofibers while fabrication of drug loaded nanofibers for poorly soluble drug candidates. The review explores various methodological advancements in the electrospinning process and set-ups for production scale-up. The various types of electrospun nanofibers (like simple matrix, core-sheath, Janus, and inclusion complex nanofibers) that have been exploited for the delivery of poorly soluble drugs are also critically assessed. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies.
现有药物分子以及目前处于研发阶段的药物分子的水溶性差，给药物科学家带来了巨大挑战，因为它们通常表现出较差的溶解行为以及随之而来的低且不稳定的生物利用度。这引发了广泛的研究，以探索基于纳米技术的技术平台来寻求可能的解决方案。最近，纳米纤维已被广泛应用于包括药物递送在内的各种生物医学应用。静电纺丝纳米纤维能够将均匀负载的治疗剂保持在非晶态，可能会阻碍其析晶。本综述旨在概述在制备难溶性候选药物的载药纳米纤维时，影响静电纺丝过程和纳米纤维特性的各种关键因素。该综述探讨了静电纺丝过程中的各种方法学进展以及用于扩大生产规模的装置。还对已用于递送难溶性药物的各种类型的静电纺丝纳米纤维（如简单基质、核壳、Janus和包合物纳米纤维）进行了批判性评估。本文分类如下：治疗方法与药物发现>新兴技术。
