a Department of Pharmaceutics, College of Pharmacy , Shandong University , Jinan , China.
b Department of Pharmacy, Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen , Denmark.
J Drug Target. 2019 Mar;27(3):270-282. doi: 10.1080/1061186X.2018.1481413. Epub 2018 Aug 8.
Electrospun, an advanced technology, has been successfully employed for fibre production and offers many merits in novel drug delivery systems (DDSs). In recent years, electrospun has gained significant attention and attraction of the scientists in soaring numbers. This technology is superior to other technologies in fabricating the fibres which range from micrometers to manometers scale. The selection of appropriate polymers, electrospun processes and electrospun parameters play important roles in controlling the drug release while, treating serious illness. Besides, electrospraying process has similar characteristics to the electrospun and is presented briefly here. Further, in vivo and in vitro evaluations of the electrospun nanofibers are comprehensively discussed. In addition, the electrospun nanotechnology has been exploited to design drug release systems, investigate drug's pharmacokinetics and further develop DDS. The electrospun nanofibers improve bioactivity of various types of drugs including water-insoluble, soluble, anticancer and antibacterial drugs and genetic materials. In the end, the prospects and challenges in the process of designing drug-loaded electrospun nanofibers are discussed in detail.
静电纺丝是一种先进的技术，已成功用于纤维生产，并在新型药物传递系统（DDS）中提供了许多优点。近年来，静电纺丝技术引起了科学家们的极大关注和兴趣。与其他技术相比，这种技术在制造纤维方面具有优势，纤维的尺寸范围从微米到毫米级。选择合适的聚合物、静电纺丝工艺和参数在控制药物释放方面起着重要作用，同时也可以治疗严重疾病。此外，静电喷涂工艺与静电纺丝具有相似的特点，在此简要介绍。此外，还全面讨论了静电纺纳米纤维的体内和体外评价。此外，静电纺纳米技术已被用于设计药物释放系统、研究药物的药代动力学并进一步开发 DDS。静电纺纳米纤维提高了各种类型药物的生物活性，包括水溶性、脂溶性、抗癌和抗菌药物以及遗传物质。最后，详细讨论了设计载药静电纺纳米纤维过程中的前景和挑战。
