Fast Dissolution Electrospun Medicated Nanofibers for Effective Delivery of Poorly Water-Soluble Drug.

BACKGROUND

Electrospinning is developing rapidly from an earlier laboratory method into an industrial process. The clinical applications of this technique are approached in various ways through electrospun medicated nanofibers. Fast-dissolving oral drug delivery systems (DDSs) have promising commercial applications in the near future.

METHODS

Related papers have been investigated in this study, including the latest research results on electrospun nanofiber-based fast-dissolution DDSs.

RESULTS

The following related topics are concluded: 1) development of electrospinning, ranging from one-fluid blending to multi-fluid process and potential applications in the formation of medicated nanofibers involving poorly water-soluble drugs; 2) selection of appropriate polymer matrices and drug carriers for filament formation; 3) types of poorly water-soluble drugs ideal for fast oral delivery; 4) methods for evaluating fast-dissolving nanofibers; 5) mechanisms that promote the fast dissolution of poorly water-soluble drugs by electrospun nanofibers; 6) and important issues related to further development of electrospun medicated nanofibers as oral fast-dissolving drug delivery systems.

CONCLUSION AND PERSPECTIVE

Given their unique properties, electrospun-medicated nanofibers can be used as oral fast-dissolving DDSs of poorly water-soluble drugs. However, significant issues, such as scalable productions and solid dosage form conversions, need to be investigated.