通过CF-亚氨基硫鎓叶立德与偶氮化合物的串联反应实现三氟甲基取代的1,2-二氢喹喔啉和二亚胺的发散合成。
Divergent Synthesis of Trifluoromethyl-Substituted 1,2-Dihydroquinoxalines and Diimines by Cascade Reactions of CF-Imidoyl Sulfoxonium Ylides with Azo Compounds.
作者信息
Wei Guangming, Zheng Dongling, Li Chen, Chen Zhengkai, Wu Xiao-Feng
机构信息
Department of Chemistry, Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, Liaoning China.
出版信息
Org Lett. 2023 Sep 29;25(38):7046-7050. doi: 10.1021/acs.orglett.3c02718. Epub 2023 Sep 18.
A base-mediated cascade reaction of CF-imidoyl sulfoxonium ylides and azo compounds has been achieved, allowing for facile access to trifluoromethyl-substituted 1,2-dihydroquinoxalines and diimines in moderate to excellent yields. Noteworthy is that the unusual N-N bond cleavage and rearrangement of azo compounds are involved in the transformations.
实现了CF-亚胺基硫鎓叶立德与偶氮化合物的碱介导串联反应，能够以中等到优异的产率轻松获得三氟甲基取代的1,2-二氢喹喔啉和二亚胺。值得注意的是，这些转化过程涉及偶氮化合物不寻常的N-N键断裂和重排。
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