Romagnoli C, Zecca E, Tortorolo G, Diodato A, Fazzini G, Sorcini-Carta M
Arch Dis Child. 1987 Jun;62(6):580-4. doi: 10.1136/adc.62.6.580.
During the first week of life serum calcium, phosphorus, magnesium, immunoreactive thyrocalcitonin hormone, and parathyroid hormone concentrations were determined daily in 36 preterm and 29 small for gestational age, full term, healthy infants. Preterm babies with early neonatal hypocalcaemia had significantly higher concentrations of serum thyrocalcitonin hormone in the first four days of life than normocalcaemic preterm babies. Parathyroid hormone concentrations were similar in hypocalcaemic and normocalcaemic infants. In contrast, in the full term group no significant differences were detected in thyrocalcitonin hormone and parathyroid hormone patterns between hypocalcaemic and normocalcaemic subjects. This suggests two different pathogeneses for early hypocalcaemia in low birthweight infants. Hyperthyrocalcitoninaemia seems to be the main determining factor in preterm infants, while a non-hormonal pathogenesis should be considered in full term infants who are small for gestational age.
在出生后的第一周，每天对36名早产儿和29名小于胎龄的足月健康婴儿测定血清钙、磷、镁、免疫反应性甲状腺降钙素激素和甲状旁腺激素浓度。患有早期新生儿低钙血症的早产儿在出生后的头四天血清甲状腺降钙素激素浓度明显高于血钙正常的早产儿。低钙血症婴儿和血钙正常婴儿的甲状旁腺激素浓度相似。相比之下，在足月儿组中，低钙血症和血钙正常的婴儿在甲状腺降钙素激素和甲状旁腺激素模式上未检测到显著差异。这表明低出生体重儿早期低钙血症有两种不同的发病机制。高甲状腺降钙素血症似乎是早产儿的主要决定因素，而对于小于胎龄的足月儿应考虑非激素发病机制。
