Salle B L, David L, Glorieux F H, Delvin E, Senterre J, Renaud H
Pediatr Res. 1982 Jan;16(1):75-8. doi: 10.1203/00006450-198201001-00015.
For five days, three groups of six premature infants each were fed human milk and given a daily dosage of one of the following: vitamin D3 (30 micrograms), 25-OH D3 (10 micrograms) and 1,25-OH D3 (0.5 micrograms). The infants in the groups were matched for gestational age and birthweight. Administration of 25-OH De or 1,25-(OH)2 D3 did not significantly modify the course of early neonatal hypocalcemia as compared with infants receiving vitamin C3. Mean plasma Ca +/- S. D. (mg/100 ml) decreased to nadir values at 48 hr (D3: 5.7 +/-1.2; 25 OH D3: 6.8 +/- 0.9; 1.25-(OH)2 D3: 6.7 +/-1.1). A progressive increase toward normal values was seen at 120 and 168 hr in the three groups. Mean plasma immunoreactive parathyroid hormone +/- S.D. (microliters Eq/ml) followed an opposite pattern with peak values at 48 hr (D3: 231 +/- 137; 25-OH D3: 281 +/- 138; 1,25-(OH)2 D3:211 +/- 149). Mean plasma +/- S.D. 25-OH values (ng/ml) were low at 1.2 hr (8.7 +/- 4.8) n: 16) and increased significantly after 7 days of D3 (18.2 +/- 4.2 P less than 0.001) and 25-OH D3 administration (46 +/- 10.3 P less than 0.001)/Mean plasma iCT +/- S.D. (pg/ml) reached peak values at 24 hr (D3: 457 +/- 186; 25-OH D3: 415 +/- 121; 1.25-(OH)2 D3: 443 +/- 183). These data suggest that the various forms of vitamin D are well absorbed in preterm infants and that administration of vitamin D metabolites during the first days of life is not warranted for they prophylaxis of early neonatal hypocalcemia.
连续五天，将三组早产儿（每组六人）喂以母乳，并每日给予下列剂量之一：维生素D3（30微克）、25-羟基维生素D3（10微克）和1,25-二羟基维生素D3（0.5微克）。各组婴儿在胎龄和出生体重方面进行了匹配。与接受维生素D3的婴儿相比，给予25-羟基维生素D3或1,25-二羟基维生素D3并未显著改变早期新生儿低钙血症的病程。平均血浆钙±标准差（毫克/100毫升）在48小时时降至最低点（D3组：5.7±1.2；25-羟基维生素D3组：6.8±0.9；1,25-二羟基维生素D3组：6.7±1.1）。三组在120小时和168小时时均出现逐渐向正常值升高的情况。平均血浆免疫反应性甲状旁腺激素±标准差（微升当量/毫升）呈现相反的模式，在48小时时达到峰值（D3组：231±137；25-羟基维生素D3组：281±138；1,25-二羟基维生素D3组：211±149）。平均血浆±标准差25-羟基值（纳克/毫升）在1.2小时时较低（8.7±4.8，n = 16），在给予D3（18.2±4.2，P<0.001）和25-羟基维生素D3（46±10.3，P<0.001）7天后显著升高。平均血浆iCT±标准差（皮克/毫升）在24小时时达到峰值（D3组：457±186；25-羟基维生素D3组：415±121；1,25-二羟基维生素D3组：443±183）。这些数据表明，各种形式的维生素D在早产儿中吸收良好，并且在生命的最初几天给予维生素D代谢物对于预防早期新生儿低钙血症并无必要。
