Gayfield Scott, Busken Joshua, Mansur Sarmed
Internal Medicine, The University of Toledo, Toledo, USA.
Hospital Medicine, The University of Toledo, Toledo, USA.
Cureus. 2022 Aug 31;14(8):e28625. doi: 10.7759/cureus.28625. eCollection 2022 Aug.
Myasthenia gravis is an autoimmune disorder in which antibodies are formed against post-synaptic nicotinic acetylcholine receptors that lead to impeded muscle contraction and commonly affects the oculomotor muscles. Takotsubo cardiomyopathy (TTC) is a dilated cardiomyopathy that can mimic a myocardial infarction and causes reversible systolic dysfunction. This is a case of a 66-year-old Caucasian male with a known history of ocular myasthenia gravis that presented to the emergency room with worsening dyspnea secondary to a myasthenic crisis. One day, following admission, his shortness of breath failed to improve and was found to meet the diagnostic criteria for takotsubo cardiomyopathy. A brief review of 31 previous cases summarizes the current case reports, patterns, and mortality associated with the myasthenic crisis associated with TTC.
重症肌无力是一种自身免疫性疾病，在该疾病中会形成针对突触后烟碱型乙酰胆碱受体的抗体，这会导致肌肉收缩受阻，且通常会影响动眼肌。应激性心肌病（TTC）是一种扩张型心肌病，可模拟心肌梗死并导致可逆的收缩功能障碍。这是一例66岁的白种男性病例，其有重症肌无力病史，因重症肌无力危象导致呼吸困难加重而就诊于急诊室。入院一天后，他的呼吸急促未见改善，被发现符合应激性心肌病的诊断标准。对之前31例病例的简要回顾总结了目前与应激性心肌病相关的重症肌无力危象的病例报告、模式及死亡率。
