Einsele H, Clemens M R, Remmer H
Arch Toxicol. 1987;60(1-3):163-6. doi: 10.1007/BF00296972.
Incubating isolated erythrocytes in phosphate buffered saline supplied with sufficient glucose (20 mM) for several days resulted in methemoglobin formation and decrease in glycolytic and antioxidant enzyme activities. Volatile hydrocarbon gas release (ethane, ethylene, propane, butane, isobutane, pentane) and loss of the polyunsaturated fatty acids, arachidonic acid (20:4) and docosahexaenoic acid (22:6) in the erythrocyte membrane indicated possible involvement of peroxidative reactions in cellular aging processes.
将分离出的红细胞置于含有足够葡萄糖（20 mM）的磷酸盐缓冲盐溶液中培养数天，会导致高铁血红蛋白形成，并使糖酵解和抗氧化酶活性降低。红细胞膜中挥发性烃类气体释放（乙烷、乙烯、丙烷、丁烷、异丁烷、戊烷）以及多不饱和脂肪酸花生四烯酸（20:4）和二十二碳六烯酸（22:6）的损失表明，过氧化反应可能参与了细胞衰老过程。
