Factors influencing the caffeine test for cytochrome P 448-dependent liver function.
作者信息
Joeres R, Klinker H, Huesler H, Epping J, Hofstetter G, Drost D, Reuss H, Zilly W, Richter E
出版信息
Arch Toxicol. 1987;60(1-3):93-4. doi: 10.1007/BF00296957.
PMID:3619652
Abstract
Liver functions in patients with liver disease can be estimated by caffeine clearance. Our data, however, demonstrate the additional influence of factors other than liver disease on the caffeine test. Smoking enhances caffeine clearance in both healthy volunteers and patients with severe hepatic disorders, whereas co-medication with mexiletine strongly inhibits caffeine elimination.
摘要
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