美西律对咖啡因消除的影响。
Influence of mexiletine on caffeine elimination.
作者信息
Joeres R, Klinker H, Heusler H, Epping J, Richter E
出版信息
Pharmacol Ther. 1987;33(1):163-9. doi: 10.1016/0163-7258(87)90046-5.
PMID:3628469
Abstract
In an acute experiment in healthy volunteers and in patients under long-term treatment for cardiac arrhythmias, mexiletine inhibits caffeine elimination by about 50%. The clearance of mexiletine is not influenced by caffeine. Some side effects of mexiletine may possibly at least partially be attributable to a retention of caffeine.
摘要
在一项针对健康志愿者以及长期接受心律失常治疗的患者的急性实验中，美西律可使咖啡因的清除率降低约50%。咖啡因对美西律的清除率没有影响。美西律的某些副作用可能至少部分归因于咖啡因的潴留。
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