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AFAP1-AS1 高表达与消化系统癌症预后不良相关：一项荟萃分析。

High expression of AFAP1-AS1 is associated with poor prognosis of digestive system cancers: A meta-analysis.

机构信息

School of Traditional Chinese Medicine (Zhongjing College), Henan University of Traditional Chinese Medicine, Zhengzhou, China.

Laboratory of Molecular Pathology and Medicine, Zhengzhou University Tumor Hospital, Zhengzhou, China.

出版信息

Medicine (Baltimore). 2022 Sep 23;101(38):e30833. doi: 10.1097/MD.0000000000030833.

DOI:10.1097/MD.0000000000030833
PMID:36197192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9509167/
Abstract

BACKGROUND

Actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1) is associated with prognosis in many cancers. The aim of this study was to systematically evaluate the potential correlation between AFAP1-AS1 and the prognosis of digestive system cancers (DSC).

METHODS

EMBASE, Web of Science, Cochrane Library, PubMed, Wanfang Data (Chinese), and CNKI (Chinese) were comprehensively searched for literature published from the establishment of the database to September 2021.All case-control studies that met the inclusion criteria were retrieved; additionally manual retrieval and literature tracing was performed. After extracting the relevant data, Revman 5.3.5 software was used for meta-analysis.

RESULTS

Eighteen studies were included in analyses, high expression of AFAP1-AS1 was significantly correlated with poor prognosis in DSC, including overall survival (HR = 1.93, 95% CI: 1.72-2.17, P < .001) and disease-free survival/progression-free survival (HR = 1.87, 95% CI: 1.56-2.26, P < .001). In addition, the expression of AFAP1-AS1 was significantly correlated with tumor size, tumor stage, and lymph node metastasis.

CONCLUSION

High expression of AFAP1-AS1 was associated with poor prognosis in DSC. Therefore, it could be used as a potential marker for evaluating prognosis in DSC.

摘要

背景

肌动蛋白丝相关蛋白 1 反义 RNA 1（AFAP1-AS1）与许多癌症的预后相关。本研究旨在系统评估 AFAP1-AS1 与消化系统癌症（DSC）预后之间的潜在相关性。

方法

全面检索 EMBASE、Web of Science、Cochrane Library、PubMed、万方数据（中文）和中国知网（CNKI）（中文）自数据库建立以来至 2021 年 9 月发表的文献。检索符合纳入标准的病例对照研究，并进行手动检索和文献追溯。提取相关数据后，使用 Revman 5.3.5 软件进行荟萃分析。

结果

纳入 18 项研究进行分析，AFAP1-AS1 高表达与 DSC 的不良预后显著相关，包括总生存期（HR=1.93，95%CI：1.72-2.17，P<.001）和无病生存期/无进展生存期（HR=1.87，95%CI：1.56-2.26，P<.001）。此外，AFAP1-AS1 的表达与肿瘤大小、肿瘤分期和淋巴结转移显著相关。

结论

AFAP1-AS1 的高表达与 DSC 的不良预后相关。因此，它可以作为评估 DSC 预后的潜在标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5fc/9509167/3babf4be95c2/medi-101-e30833-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5fc/9509167/d1784d8a05c8/medi-101-e30833-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5fc/9509167/6c5b4e26942e/medi-101-e30833-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5fc/9509167/b7eccfb599f8/medi-101-e30833-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5fc/9509167/d4feeb3ce378/medi-101-e30833-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5fc/9509167/3babf4be95c2/medi-101-e30833-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5fc/9509167/d1784d8a05c8/medi-101-e30833-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5fc/9509167/6c5b4e26942e/medi-101-e30833-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5fc/9509167/b7eccfb599f8/medi-101-e30833-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5fc/9509167/d4feeb3ce378/medi-101-e30833-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5fc/9509167/3babf4be95c2/medi-101-e30833-g005.jpg

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