García-Millan Cristina, Pino Ander, Rodrigues Rita, Segurado-Miravalles Gonzalo, Alegre-Sánchez Adrián, Jaén Pedro, Anitua Eduardo
Grupo de Dermatología Pedro Jaén, Madrid, Spain.
BTI Biotechnology Institute, Vitoria, Spain.
Clin Cosmet Investig Dermatol. 2022 Sep 29;15:2077-2086. doi: 10.2147/CCID.S379323. eCollection 2022.
Although the underlying pathophysiology of sensitive skin remains unknown, it presents clinical symptoms like erythema, burning and dryness associated with other inflammatory dermatoses such as dermatitis or rosacea.
The aim of the present report was to provide preliminary data about the efficacy of Endoret-Serum (ES) as an autologous therapy for the topical management of sensitive skin alterations.
Five patients underwent a daily topical ES treatment that was maintained for three months. Clinical assessment was carried out using validated dermatological surveys (DLQI, IGA, Likert, PGI-I). Additionally, skin hydration measurement and high-resolution topographic and reflectance confocal imaging analysis were carried out.
No adverse events were observed during the treatment. At the end of the follow-up period, surveys highlighted a significant therapeutic effect compared to baseline. Skin hydration was also improved, and topographic images showed a decrease in patient's underlying inflammatory and vascular condition.
This preliminary report suggests that Endoret-Serum may be useful in the management of clinical symptoms derived from sensitive skin alterations.
尽管敏感性皮肤的潜在病理生理学仍不明确，但它会出现如红斑、灼痛和干燥等临床症状，这些症状与其他炎症性皮肤病如皮炎或玫瑰痤疮相关。
本报告旨在提供关于Endoret-Serum（ES）作为一种自体疗法用于局部治疗敏感性皮肤改变的疗效的初步数据。
五名患者接受了为期三个月的每日局部ES治疗。使用经过验证的皮肤病学调查（DLQI、IGA、Likert、PGI-I）进行临床评估。此外，还进行了皮肤水合测量以及高分辨率地形和反射共聚焦成像分析。
治疗期间未观察到不良事件。在随访期结束时，调查显示与基线相比有显著的治疗效果。皮肤水合情况也得到改善，地形图像显示患者潜在的炎症和血管状况有所减轻。
这份初步报告表明，Endoret-Serum可能有助于管理源自敏感性皮肤改变的临床症状。
