Zaki Shifa Nurzahra, Oktarina Caroline, Purwoko Reza Yuridian, Sutanto Hans Utama
Dr. Zaki is with the Faculty of Medicine at Trisakti University in Jakarta, Indonesia.
Dr. Mardyansyah is with the Faculty of Medicine, Trisakti University, Jakarta, Indonesia.
J Clin Aesthet Dermatol. 2024 Jul;17(7):43-49.
Atopic dermatitis (AD) is a chronic inflammatory skin disease which is associated with a significantly decreased quality of life. Overall, the conventional treatment approaches for moderate to severe AD are prone to relapses. Hence, the exploration of new adjuvant therapies, such as the use of platelet-rich plasma (PRP), is expected to enhance the effectiveness of existing interventions, which remain paramount in improving the quality of life for patients with moderate to severe relapsing AD.
The literature search primarily focused on original English-language articles on PRP as a therapeutic approach for the management of adult AD. Literature reviews, systematic literature, and meta-analyses were excluded. The databases searched include PubMed/Medline, Science Direct, and Cochrane, up to October 2023. Seven articles were reviewed.
PRP is reported to be used as a therapy for AD in both injectable and topical forms. Various studies showed that PRP could significantly reduce free radical accumulation, proinflammatory mediators, provide healing environment, and restore the metabolic activity disruption. Clinically, PRP therapy was reported to improve clinical symptoms, patient's satisfaction, quality of life, and reduce frequent recurrence. Mild side effects (pain and ecchymosis) due to the injection were reported. Another advantage is that it is safe to be used in pregnant and breastfeeding women.
Heterogeneity of methods in preparing PRP and further research with larger scale standardized protocols are warranted.
PRP yields favorable outcomes when used in AD treatment and can serve as an alternative for moderate to severe or refractory AD through its anti-inflammatory and proliferative properties.
特应性皮炎（AD）是一种慢性炎症性皮肤病，与生活质量显著下降相关。总体而言，中重度AD的传统治疗方法容易复发。因此，探索新的辅助治疗方法，如使用富血小板血浆（PRP），有望提高现有干预措施的有效性，这对于改善中重度复发性AD患者的生活质量仍然至关重要。
文献检索主要集中在以英文发表的关于PRP作为成人AD治疗方法的原创文章。排除文献综述、系统文献和荟萃分析。检索的数据库包括截至2023年10月的PubMed/Medline、Science Direct和Cochrane。共审查了7篇文章。
据报道，PRP可通过注射和局部应用两种形式用于AD治疗。各种研究表明，PRP可以显著减少自由基积累、促炎介质，提供愈合环境，并恢复代谢活性紊乱。临床上，据报道PRP治疗可改善临床症状、患者满意度、生活质量，并减少频繁复发。有报道称注射会引起轻微副作用（疼痛和瘀斑）。另一个优点是它对孕妇和哺乳期妇女使用安全。
制备PRP的方法存在异质性，需要采用更大规模的标准化方案进行进一步研究。
PRP用于AD治疗时产生了良好的效果，通过其抗炎和增殖特性，可作为中重度或难治性AD的一种替代治疗方法。
