Novel Cold Cure Acrylic Denture Base with Recycled Zirconia Nano-Fillers That Were Functionalized by HEMA Agent Incorporation: Using the Sprinkle Approach. 新型冷固化丙烯酸义齿基托，采用 HEMA 试剂复合功能化回收氧化锆纳米填料：撒粉法。
Novel Cold Cure Acrylic Denture Base with Recycled Zirconia Nano-Fillers That Were Functionalized by HEMA Agent Incorporation: Using the Sprinkle Approach.
机构信息
Faculty of Dentistry-Cairo University, Department of Orthodontics, Cairo, Egypt.
Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Beni-Suef, Egypt.
出版信息
Int J Nanomedicine. 2022 Sep 29;17:4639-4658. doi: 10.2147/IJN.S374258. eCollection 2022.
BACKGROUND
Though acrylic resins possess many useful properties, denture fracture is nevertheless a familiar issue.
OBJECTIVE
This study aimed to determine the effect of low-percent recycled Zirconia nanoparticles as filler on the transverse strength, impact strength, surface hardness, water sorption, and solubility of resin using the sprinkle cold-curing technique.
MATERIALS AND METHODS
Various formulae were prepared and mixed with PMMA (polymer) powder containing varying percentages (0.01%, 0.1%, 0.3%, and 0.5%) of recycled ZrO2NPs to mono-methyl methacrylate (MMA monomer). A 2-hydroxyethyl-methacrylate (HEMA) agent was used to functionalize recycled zirconia (ZrO) nano-fillers. X-ray diffraction, field emission scanning electron microscopy, high-resolution transmission electron microscopy, energy-dispersive X-ray spectroscopy, and dynamic light scattering were used to characterize the samples. For mechanical tests, standard metallic moulds (according to American Dental Association specification no. 27) were machined for 60 specimens' preparation, 12 for each percent (zero, 0.01%, 0.1%, 0.3%, and 0.5%). A one-way ANOVA test was used to compare the five groups for parametric data, while the Kruskal-Wallis test was employed for nonparametric data. The 0.05 value was accepted as the significance level. All formulae were tested for cytotoxicity at 24 and 48 hours on WI38 normal lung cell lines.
RESULTS
The XRD analysis demonstrated the tetragonal crystallographic structure of the recycled zirconia nanoparticles. Incorporating a low percentage of recycled ZrO nanoparticles (0.01%, 0.1%, 0.3%, and 0.5%) improved the tested properties of PMMA to different degrees in a significant and non-significant pattern, while the optimal tested percent was 0.3%.
CONCLUSION
The 0.3% percentage of recycled zirconia nanoparticles maintained and improved the physical and mechanical properties of acrylic resin. Recycled ZrO/PMMA nanocomposite is a synergistic candidate due to its economic return and clinical application safety.
背景
尽管丙烯酸树脂具有许多有用的特性，但义齿断裂仍然是一个常见的问题。
目的
本研究旨在通过撒粉冷固化技术，确定低百分比回收氧化锆纳米粒子作为填料对树脂的横向强度、冲击强度、表面硬度、吸水率和溶解度的影响。
材料和方法
用聚甲基丙烯酸甲酯（聚合物）粉末与不同百分比（0.01%、0.1%、0.3%和 0.5%）的回收氧化锆纳米粒子混合，制备各种配方，并与单体甲基丙烯酸甲酯（MMA）混合。用 2-羟乙基甲基丙烯酸酯（HEMA）对回收氧化锆（ZrO）纳米填料进行功能化。采用 X 射线衍射、场发射扫描电子显微镜、高分辨率透射电子显微镜、能谱和动态光散射对样品进行表征。为了进行力学测试，根据美国牙科协会规范 No.27 加工标准金属模具，制备 60 个试件，每个百分比（零、0.01%、0.1%、0.3%和 0.5%）各 12 个。对参数数据采用单向方差分析检验比较五组，对非参数数据采用 Kruskal-Wallis 检验。接受 0.05 作为显著水平。所有配方均在 24 和 48 小时对 WI38 正常肺细胞系进行细胞毒性测试。
结果
XRD 分析表明回收氧化锆纳米粒子具有四方晶相结构。在 PMMA 中加入低百分比的回收氧化锆纳米粒子（0.01%、0.1%、0.3%和 0.5%），以显著和非显著的方式不同程度地提高了 PMMA 的测试性能，而最佳测试百分比为 0.3%。
结论
0.3%的回收氧化锆纳米粒子保持并提高了丙烯酸树脂的物理和机械性能。由于其经济回报和临床应用安全性，回收 ZrO/PMMA 纳米复合材料是一种协同候选材料。
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