Qi Kuo, Liu Rong
The First Clinical Medical College, Inner Mongolia Medical University, Hohhot 010110, China.
Translational Cancer Research Center, Peking University First Hospital, Beijing 100034, China.
Chin J Cancer Res. 2022 Aug 30;34(4):422-424. doi: 10.21147/j.issn.1000-9604.2022.04.10.
Hepatobiliary tumors are of high grade of heterogeneity, which is recognized as a key contributor to drug resistance and poor disease prognosis. However, the intrinsic mechanism between heterogeneity and drug response in hepatobiliary tumor is still largely unknown. Using tumor organoid models, Wang and her colleagues have found that cooperation among distinct subpopulations might be a key mechanism for drug resistance in hepatobiliary tumor.
肝胆肿瘤具有高度的异质性，这被认为是耐药性和疾病预后不良的关键因素。然而，肝胆肿瘤异质性与药物反应之间的内在机制仍 largely unknown。利用肿瘤类器官模型，王和她的同事们发现不同亚群之间的合作可能是肝胆肿瘤耐药的关键机制。
