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基于丝肽-透明质酸的纳米凝胶用于增强姜黄素的局部给药。

Silk peptide-hyaluronic acid based nanogels for the enhancement of the topical administration of curcumin.

作者信息

Niu Jiangxiu, Yuan Ming, Liu Yao, Wang Liye, Tang Zigui, Wang Yihan, Qi Yueheng, Zhang Yansong, Ya Huiyuan, Fan Yanli

机构信息

College of Food and Drug, Henan Functional Cosmetics Engineering and Technology Research Center, Luoyang Normal University, Luoyang, Henan, China.

Department of Pharmacy, Henan Medical College, Zhengzhou, China.

出版信息

Front Chem. 2022 Sep 19;10:1028372. doi: 10.3389/fchem.2022.1028372. eCollection 2022.

DOI:10.3389/fchem.2022.1028372
PMID:36199664
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9527322/
Abstract

The present study focused on the development of Cur-loaded SOHA nanogels (Cur-SHNGs) to enhance the topical administration of Cur. The physiochemical properties of Cur-SHNGs were characterized. Results showed that the morphology of the Cur-SHNGs was spherical, the average size was 171.37 nm with a zeta potential of -13.23 mV. Skin permeation experiments were carried out using the diffusion cell systems. It was found that the skin retention of Cur-SHNGs was significantly improved since it showed the best retention value (0.66 ± 0.17 μg/cm). In addition, the hematoxylin and eosin staining showed that the Cur-SHNGs improved transdermal drug delivery by altering the skin microstructure. Fluorescence imaging indicated that Cur-SHNGs could effectively deliver the drug to the deeper layers of the skin. Additionally, Cur-SHNGs showed significant analgesic and anti-inflammatory activity with no skin irritation. Taken together, Cur-SHNGs could be effectively used for the topical delivery of therapeutic drugs.

摘要

本研究聚焦于载有姜黄素的大豆油酰羟肟酸纳米凝胶（Cur-SHNGs）的开发，以增强姜黄素的局部给药效果。对Cur-SHNGs的理化性质进行了表征。结果表明，Cur-SHNGs的形态为球形，平均粒径为171.37 nm，zeta电位为-13.23 mV。使用扩散池系统进行了皮肤渗透实验。结果发现，Cur-SHNGs的皮肤滞留量显著提高，因为其显示出最佳的滞留值（0.66±0.17μg/cm）。此外，苏木精和伊红染色表明，Cur-SHNGs通过改变皮肤微观结构改善了透皮给药。荧光成像表明，Cur-SHNGs能够有效地将药物递送至皮肤深层。此外，Cur-SHNGs显示出显著的镇痛和抗炎活性，且无皮肤刺激性。综上所述，Cur-SHNGs可有效地用于治疗药物的局部递送。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/9527322/ac12faa52f4f/fchem-10-1028372-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/9527322/1ae68449c22f/fchem-10-1028372-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/9527322/7acb669c41d0/fchem-10-1028372-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/9527322/20cab6cd13b6/fchem-10-1028372-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/9527322/0624f47ccd62/fchem-10-1028372-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/9527322/1b4d2ab910d2/fchem-10-1028372-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/9527322/e79e2bfcb725/fchem-10-1028372-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/9527322/55801991c976/fchem-10-1028372-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/9527322/34ffead6fac7/fchem-10-1028372-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/9527322/ac12faa52f4f/fchem-10-1028372-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/9527322/1ae68449c22f/fchem-10-1028372-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/9527322/7acb669c41d0/fchem-10-1028372-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/9527322/20cab6cd13b6/fchem-10-1028372-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/9527322/0624f47ccd62/fchem-10-1028372-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/9527322/1b4d2ab910d2/fchem-10-1028372-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/9527322/e79e2bfcb725/fchem-10-1028372-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/9527322/55801991c976/fchem-10-1028372-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/9527322/34ffead6fac7/fchem-10-1028372-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/9527322/ac12faa52f4f/fchem-10-1028372-g009.jpg

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引用本文的文献

[1]
Studying the Effect of Reducing Agents on the Properties of Gold Nanoparticles and Their Integration into Hyaluronic Acid Hydrogels.

Molecules. 2024-12-11

[2]
Hyaluronic Acid Nanogels: A Promising Platform for Therapeutic and Theranostic Applications.

Pharmaceutics. 2023-11-25

[3]
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RSC Adv. 2023-10-4

[4]
Microemulsion-Based Keratin-Chitosan Gel for Improvement of Skin Permeation/Retention and Activity of Curcumin.

Gels. 2023-7-21

本文引用的文献

[1]
Collagen-coated silk fibroin nanofibers with antioxidants for enhanced wound healing.

J Biomater Sci Polym Ed. 2023-1

[2]
Enhanced transdermal insulin basal release from silk fibroin (SF) hydrogels via iontophoresis.

Drug Deliv. 2022-12

[3]
Preparation and Characterization of Lidocaine-Loaded, Microemulsion-Based Topical Gels.

Iran J Pharm Res. 2022-1-12

[4]
Novel Hyaluronic Acid ethosomes based gel formulation for topical use with reduced toxicity, better skin permeation, deposition, and improved pharmacodynamics.

J Liposome Res. 2023-6

[5]
Pentapeptide modified ethosomes for enhanced skin retention and topical efficacy activity of indomethacin.

Drug Deliv. 2022-12

[6]
Development of lipid nanoparticles for transdermal loteprednol etabonate delivery.

J Microencapsul. 2022-6

[7]
Chitosan-coated nanostructured lipid carriers for transdermal delivery of tetrahydrocurcumin for breast cancer therapy.

Carbohydr Polym. 2022-7-15

[8]
Hyaluronan-modified transfersomes based hydrogel for enhanced transdermal delivery of indomethacin.

Drug Deliv. 2022-12

[9]
Transdermal delivery of poly-hyaluronic acid-based spherical nucleic acids for chemogene therapy.

Nanoscale. 2022-2-3

[10]
Transdermal Delivery of Curcumin-Loaded Solid Lipid Nanoparticles as Microneedle Patch: an In Vitro and In Vivo Study.

AAPS PharmSciTech. 2022-1-5

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