Zhang Tai, Zhang Beihua, Tian Wende, Wang Fengyun, Zhang Jiaqi, Ma Xiangxue, Wei Yuchen, Tang Xudong
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Department of Gastroenterology, Xiyuan Hospital, China Academy of Traditional Chinese Medical Sciences, Beijing, China.
Front Pharmacol. 2022 Sep 9;13:951004. doi: 10.3389/fphar.2022.951004. eCollection 2022.
Ulcerative colitis (UC) is an idiopathic inflammatory bowel disease with repeated relapses and remissions. Despite decades of effort, numerous aspects, including the initiating event and pathogenesis of UC, still remain ambiguous, which requires ongoing investigation. Given the mass of publications on UC, there are multidimensional challenges to evaluating the scientific impact of relevant work and identifying the current foci of the multifaceted disease. Accordingly, herein, we aim to assess the global growth of UC research production, analyze patterns of research areas, and evaluate trends in this area. The Web of Science Core Collection of Clarivate Analytics was searched for articles related to UC published from 2011 to 2021. Microsoft Office Excel 2019 was used to visualize the number of publications over time. Knowledge maps were generated using CiteSpace and VOSviewer to analyze collaborations among countries, institutions, and authors and to present the journey of UC research as well as to reveal the current foci of UC research. A total of 5,088 publications were evaluated in the present study. China had the most publications (1,099, 22.5%). Univ Calif San Diego was the most productive institution (126, 2.48%). William J Sandborn published the greatest number of articles (100, 1.97%). Toshifumi Hibi was the most influential author in the field with a betweenness centrality of 0.53. was identified as the most prolific journal (379, 7.45%). was the most co-cited journal (3,730, 4.02%). "Vedolizumab," "tofacitinib," "," "fecal microbiota transplantation (FMT)," "toll-like receptor 4," and "nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome" were considered the hot topics. In UC research, manuscripts that had high impacts on the scientific community provided an evidence base. UC therapy has entered the era of personalized and precision therapy. As research on FMT, anti-integrin antibodies, Janus kinase inhibitors, and anti-tumor necrosis factor drugs continues to grow, their use in the clinical setting may also expand.
溃疡性结肠炎（UC）是一种具有反复复发和缓解特点的特发性炎症性肠病。尽管经过了数十年的努力，但包括UC的起始事件和发病机制在内的许多方面仍然不明确，这需要持续研究。鉴于关于UC的大量出版物，评估相关工作的科学影响以及确定这种多方面疾病的当前研究重点面临多维度挑战。因此，在本文中，我们旨在评估UC研究产出的全球增长情况，分析研究领域模式，并评估该领域的趋势。在科睿唯安的Web of Science核心合集中搜索了2011年至2021年发表的与UC相关的文章。使用Microsoft Office Excel 2019来可视化随时间变化的出版物数量。使用CiteSpace和VOSviewer生成知识图谱，以分析国家、机构和作者之间的合作情况，展示UC研究的历程，并揭示UC研究的当前重点。本研究共评估了5088篇出版物。中国的出版物数量最多（1099篇，占22.5%）。加利福尼亚大学圣地亚哥分校是产出最多的机构（126篇，占2.48%）。威廉·J·桑德伯恩发表的文章数量最多（100篇，占1.97%）。日比俊文是该领域最具影响力的作者，中间中心性为0.53。《 》被确定为发文量最多的期刊（379篇，占7.45%）。《 》是被引频次最高的期刊（3730次，占4.02%）。“维多珠单抗”“托法替布”“ ”“粪便微生物群移植（FMT）”“Toll样受体4”和“核苷酸结合寡聚化结构域样受体蛋白3炎性小体”被视为热门话题。在UC研究中，对科学界有高影响力的手稿提供了证据基础。UC治疗已进入个性化和精准治疗时代。随着对FMT、抗整合素抗体、Janus激酶抑制剂和抗肿瘤坏死因子药物的研究不断增加，它们在临床环境中的应用可能也会扩大。
