Ji Lijiang, Zhou Qiong, Huang Jinke, Lu Dongxue
Department of Anorectal Surgery, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, 215500, Jiangsu, China.
Graduate School, Beijing University of Chinese Medicine, Beijing, 100105, China.
Heliyon. 2023 Sep 17;9(9):e20195. doi: 10.1016/j.heliyon.2023.e20195. eCollection 2023 Sep.
Despite the many reported studies on macrophages in ulcerative colitis (UC), the overall research trends in this field are unclear. This study evaluates the research trends and hotspots regarding macrophages in UC using bibliometric analysis.
A systematic search was conducted in the Web of Science database to identify publications related to macrophages in UC from 2012 to 2021. R package 'bibliometrix', VOSviewers, CiteSpace and Microsoft Excel were utilised for the bibliometric analysis.
1074 articles published between 2012 and 2021 were analysed. The number of publications on macrophages in UC showed a consistently increasing trend, with USA and China as the leading contributors to this field. Notably, Georgia State University and Nanjing University contributed significantly to this field. Among the authors, Wang Y had the highest productivity, while Wu X received the most citations. The journal was identified as the most authoritative journal in this field. Co-citation analysis revealed that the exploration of the mechanisms of macrophages in UC through in vivo and in vitro experiments was the primary focus of research. Moreover, the emerging research hotspots included keywords such as 'macrophage polarization', 'gut microbiota' and 'NLRP3 inflammasome'.
Research on macrophages in UC holds significant value and practical implications. Additionally, China demonstrated prolific output in this field, while the USA had the most influential contributions. Currently, research hotspots are centred around the modulation of gut microbiota to regulate macrophage polarization and macrophage pyroptosis as potential strategies for mitigating UC.
尽管已有许多关于溃疡性结肠炎（UC）中巨噬细胞的研究报道，但该领域的总体研究趋势尚不清楚。本研究采用文献计量分析方法评估UC中巨噬细胞的研究趋势和热点。
在Web of Science数据库中进行系统检索，以识别2012年至2021年期间与UC中巨噬细胞相关的出版物。利用R包“bibliometrix”、VOSviewer、CiteSpace和Microsoft Excel进行文献计量分析。
分析了2012年至2021年发表的1074篇文章。UC中关于巨噬细胞的出版物数量呈持续增长趋势，美国和中国是该领域的主要贡献者。值得注意的是，佐治亚州立大学和南京大学对该领域贡献显著。在作者中，王Y的产出率最高，而吴X的被引次数最多。该期刊被确定为该领域最具权威性的期刊。共被引分析表明，通过体内和体外实验探索UC中巨噬细胞的机制是研究的主要重点。此外，新兴的研究热点包括“巨噬细胞极化”、“肠道微生物群”和“NLRP3炎性小体”等关键词。
UC中巨噬细胞的研究具有重要价值和实际意义。此外，中国在该领域的产出颇丰，而美国的贡献最具影响力。目前，研究热点集中在调节肠道微生物群以调节巨噬细胞极化和巨噬细胞焦亡，作为减轻UC的潜在策略。
