12/15-脂氧合酶及其多种代谢产物在炎症反应中作为多种多不饱和脂肪酸底物的作用。
The Role of 12/15-Lipoxygenase and Its Various Metabolites Generated from Multiple Polyunsaturated Fatty Acids as Substrates in Inflammatory Responses.
机构信息
Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing 100730, China.
Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China.
出版信息
Biomed Res Int. 2022 Sep 25;2022:4589191. doi: 10.1155/2022/4589191. eCollection 2022.
12/15-lipoxygenase (12/15-LOX) is a member of the lipoxygenase family, which can catalyze a variety of polyunsaturated fatty acids (PUFA) to produce different metabolites, such as 12-hydroxyeicosatetraenoic acid (12-HETE), 15-HETE, lipoxin (LX), hepoxilin, resolvin, protectin, and maresins. 12/15-LOX and its metabolites take part in inflammatory responses and mediate related signalling pathways, playing an essential role in various inflammatory diseases. So the definition, catalytic substrates, metabolites of 12/15-lipoxygenase, and their roles in inflammatory responses are reviewed in this article.
12/15-脂氧合酶（12/15-LOX）是脂氧合酶家族的一员，它可以催化多种多不饱和脂肪酸（PUFA）产生不同的代谢物，如 12-羟基二十碳四烯酸（12-HETE）、15-HETE、脂氧素（LX）、海普林、解析素、保护素和maresin。12/15-LOX 及其代谢物参与炎症反应并介导相关信号通路，在各种炎症性疾病中发挥重要作用。因此，本文综述了 12/15-脂氧合酶的定义、催化底物、代谢物及其在炎症反应中的作用。
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