Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Department of Emergency, Taihe Hospital, Shiyan, China.
Cell Prolif. 2022 Dec;55(12):e13327. doi: 10.1111/cpr.13327. Epub 2022 Oct 5.
Mitophagy refers to the selective self-elimination of mitochondria under damaged or certain developmental conditions. As an important regulatory mechanism to remove damaged mitochondria and maintain the internal and external cellular balance, mitophagy plays pivotal roles in carcinogenesis and progression as well as treatment.
Here, we combined data from recent years to comprehensively describe the regulatory mechanisms of mitophagy and its multifaceted significance in cancer, and discusse the potential of targeted mitophagy as a cancer treatment strategy.
The molecular mechanisms regulating mitophagy are complex, diverse, and cross-talk. Inducing or blocking mitophagy has the same or completely different effects in different cancer contexts. Mitophagy plays an indispensable role in regulating cancer metabolic reprogramming, cell stemness, and chemotherapy resistance for better adaptation to tumor microenvironment. In cancer cell biology, mitophagy is considered to be a double-edged sword. And to fully understand the role of mitophagy in cancer development can provide new targets for cancer treatment in clinical practice.
This review synthesizes a large body of data to comprehensively describe the molecular mechanisms of mitophagy and its multidimensional significance in cancer and cancer treatment, which will undoubtedly deepen the understanding of mitophagy.
自噬是指在受损或特定发育条件下，线粒体的选择性自我消除。作为一种清除受损线粒体并维持内外细胞平衡的重要调节机制，自噬在癌症的发生和发展以及治疗中起着关键作用。
在这里，我们结合近年来的数据，全面描述了自噬的调节机制及其在癌症中的多方面意义，并讨论了靶向自噬作为癌症治疗策略的潜力。
调节自噬的分子机制复杂、多样且相互交流。在不同的癌症环境中，诱导或阻断自噬会产生相同或完全不同的效果。自噬在调节癌症代谢重编程、细胞干性和化疗耐药性方面发挥着不可或缺的作用，以更好地适应肿瘤微环境。在癌症细胞生物学中，自噬被认为是一把双刃剑。充分了解自噬在癌症发展中的作用，可以为临床实践中的癌症治疗提供新的靶点。
本综述综合了大量数据，全面描述了自噬的分子机制及其在癌症和癌症治疗中的多维意义，这无疑将加深对自噬的理解。
