Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
The Center of Gastrointestinal and Minimally Invasive Surgery, Department of General Surgery, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu 610031, China.
Theranostics. 2023 Jan 1;13(2):736-766. doi: 10.7150/thno.79876. eCollection 2023.
Cellular mitophagy means that cells selectively wrap and degrade damaged mitochondria through an autophagy mechanism, thus maintaining mitochondria and intracellular homeostasis. In recent years, mitophagy has received increasing attention as a research hotspot related to the pathogenesis of clinical diseases, such as neurodegenerative diseases, cardiovascular diseases, cancer, metabolic diseases, and so on. It has been found that the regulation of mitophagy may become a new direction for the treatment of some diseases. In addition, numerous small molecule modulators of mitophagy have also been reported, which provides new opportunities to comprehend the procedure and potential of therapeutic development. Taken together, in this review, we summarize current understanding of the mechanism of mitophagy, discuss the roles of mitophagy and its relationship with diseases, introduce the existing small-molecule pharmacological modulators of mitophagy and further highlight the significance of their development.
细胞线粒体自噬是指细胞通过自噬机制选择性地包裹和降解受损的线粒体，从而维持线粒体和细胞内的平衡。近年来，线粒体自噬作为与神经退行性疾病、心血管疾病、癌症、代谢性疾病等临床疾病发病机制相关的研究热点受到越来越多的关注。研究发现，调节线粒体自噬可能成为治疗某些疾病的新方向。此外，还报道了许多线粒体自噬的小分子调节剂，为理解其治疗发展的过程和潜力提供了新的机会。总之，在这篇综述中，我们总结了目前对线粒体自噬机制的认识，讨论了线粒体自噬的作用及其与疾病的关系，介绍了现有的线粒体自噬小分子药理学调节剂，并进一步强调了它们开发的意义。
