Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, China.
Dermatol Ther. 2022 Dec;35(12):e15905. doi: 10.1111/dth.15905. Epub 2022 Oct 17.
Rosacea is a kind of chronic inflammatory skin disease that usually occurs in the middle of the face. Diammonium glycyrrhizinate (DG), an effective monomer component extracted from licorice, has extensive anti-inflammatory, antioxidant, anti-allergic, and immunomodulatory effects. There is no research on its therapeutic effect on rosacea. In this study, we divided rosacea patients mainly characterized by papules and pustules randomly into three groups. Group A received clarithromycin 500 mg once a day, isotretinoin 10 mg once a day; Group B received DG 150 mg three times a day, other medicines were the same as Group A; Group C received clarithromycin 250 mg once a day, isotretinoin 10 mg once every 2 days, and DG 150 mg three times a day. All patients' symptom scores and laboratory tests were evaluated when followed up. We found that DG combined with clarithromycin and isotretinoin in the treatment of rosacea was more effective and quicker than clarithromycin and isotretinoin alone. Moreover, half common dosage of clarithromycin and isotretinoin combined with DG could achieve the same therapeutic effect as the conventional dose, and brought about lower incidences of adverse events (AEs). Therefore, it is recommended to use half common dosage of routine medication combined with DG for rosacea patients mainly characterized by papules and pustules.
酒渣鼻是一种慢性炎症性皮肤疾病，通常发生在面部中部。甘草酸二铵（DG）是从甘草中提取的一种有效的单体成分，具有广泛的抗炎、抗氧化、抗过敏和免疫调节作用。目前尚无关于其治疗酒渣鼻疗效的研究。本研究将主要以丘疹脓疱为表现的酒渣鼻患者随机分为三组，A 组给予克拉霉素 500mg 每日 1 次、异维 A 酸 10mg 每日 1 次；B 组给予 DG 150mg 每日 3 次，其他药物与 A 组相同；C 组给予克拉霉素 250mg 每日 1 次、异维 A 酸 10mg 每 2 日 1 次、DG 150mg 每日 3 次。所有患者均在随访时评估症状评分和实验室检查。结果发现，DG 联合克拉霉素和异维 A 酸治疗酒渣鼻比单独使用克拉霉素和异维 A 酸更有效、更快。而且，DG 联合半常规剂量的克拉霉素和异维 A 酸可达到与常规剂量相同的治疗效果，不良反应（AE）发生率更低。因此，建议对于主要以丘疹脓疱为表现的酒渣鼻患者，使用半常规剂量的常规药物联合 DG 治疗。
