Zheng Xiao, Xu Jinjuan
Xiao Zheng Department of Infectious, The First People's Hospital of Linping District, Hangzhou City, Zhejiang Province 311100, P.R. China.
Jinjuan Xu Department of General Geriatrics, Linping District Integrated Traditional Chinese and Western Medicine Hospital, Hangzhou City, Zhejiang Province 311100, P.R. China.
Pak J Med Sci. 2024 Dec;40(11):2702-2706. doi: 10.12669/pjms.40.11.10428.
To explore the hepatoprotective effect of diammonium glycyrrhizinate (DG) in the treatment of pulmonary tuberculosis.
This is a retrospective analysis of clinical data of 113 patients with pulmonary tuberculosis, admitted to The First People's Hospital of Linping District from March 2020 to December 2022. Among them, 55 patients who received conventional anti-tuberculosis treatment (2HRZE/4HR) alone were assigned to the Routine group, while 58 patients who received anti-tuberculosis treatment combined with DG treatment were assigned to the DG group. Treatment efficacy, incidence of liver injury, levels of total bilirubin (TBIL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and adverse reactions were assessed in the two groups.
The total efficacy of treatment was significantly higher, and the incidence of liver injury was significantly lower in the DG group compared to the Routine group (<0.05). After the treatment, the levels of TBIL, ALT, and AST in both groups significantly increased, and were significantly lower in the DG group than in the Routine group (<0.05). There was no significant difference in the incidence of adverse reactions between the groups (>0.05).
In the treatment of pulmonary tuberculosis, combining DG with conventional anti-tuberculosis regimen can improve overall intervention effect, reduce incidence of liver injury, and alleviate its degree.
探讨甘草酸二铵（DG）在肺结核治疗中的保肝作用。
对2020年3月至2022年12月临平区第一人民医院收治的113例肺结核患者的临床资料进行回顾性分析。其中，55例仅接受常规抗结核治疗（2HRZE/4HR）的患者被分配到常规组，58例接受抗结核治疗联合DG治疗的患者被分配到DG组。评估两组的治疗效果、肝损伤发生率、总胆红素（TBIL）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）水平及不良反应。
与常规组相比，DG组的总治疗有效率显著更高，肝损伤发生率显著更低（<0.05）。治疗后，两组的TBIL、ALT和AST水平均显著升高，且DG组显著低于常规组（<0.05）。两组间不良反应发生率无显著差异（>0.05）。
在肺结核治疗中，将DG与常规抗结核方案联合应用可提高整体干预效果，降低肝损伤发生率，并减轻其程度。
