Department of Breast Center, The Affiliated Hospital of Qingdao University, Qingdao, China.
Department of Laboratory, Qingdao University Affiliated Qingdao Women and Childrens Hospital, Qingdao, China.
Cell Biol Int. 2023 Jan;47(1):283-291. doi: 10.1002/cbin.11930. Epub 2022 Oct 6.
DDX46, a member of DEAD-box (DDX) proteins, is associated with various cancers, while its involvement in the pathogenesis of breast cancer hasn't been reported so far. The study demonstrated the overexpression of DDX46 in human breast cancer cells and tissue samples, and correlated with high histological grade and lymph node metastasis. Downregulation of DDX46 in the breast cancer cell lines inhibited their proliferation and invasiveness in vitro. Furthermore, the growth of MDA-MB-231 xenografts was suppressed in nude mice by DDX46 knockingdown. Taken together, our findings suggest that DDX46 is an oncogenic factor in human breast cancer, and a potential therapeutic target.
DDX46 是 DEAD-box（DDX）蛋白家族的成员，与多种癌症相关，但其在乳腺癌发病机制中的作用尚未见报道。本研究表明 DDX46 在人乳腺癌细胞和组织样本中呈过表达，且与高组织学分级和淋巴结转移相关。在乳腺癌细胞系中下调 DDX46 的表达可抑制其体外增殖和侵袭能力。此外，在裸鼠中，通过敲低 DDX46 抑制 MDA-MB-231 异种移植瘤的生长。综上所述，我们的研究结果表明 DDX46 是人类乳腺癌的致癌因子，也是一个潜在的治疗靶点。
