Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of Agricultural Products, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China.
Key Laboratory of Ministry of Education for Medicinal Resource and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, 710119, China.
Food Funct. 2022 Oct 31;13(21):11111-11124. doi: 10.1039/d2fo02063g.
Fu brick tea is one of the most famous microbially fermented teas that has received considerable attention owing to its promising anti-obesity capacity; however, the underlying mechanisms of its action remain largely unexplored. Herein, an eight-week oral administration of Fu brick tea aqueous extract (FTE) was observed to dose-dependently reduce body weight and abnormal fat accumulation for inguinal white adipose tissue, stimulate beige-fat development and thermogenesis in the brown adipose tissue of mice fed with a high-fat diet (HFD) ( < 0.05). FTE ameliorated HFD-induced gut dysbacteriosis and improved the microbiome ecology such that it exhibited an increased capacity to reduce the host adiposity, abnormal glycometabolism, and hepatic steatosis. FTE increased the abundance of beneficial bacteria strains, , , , , , , and , accompanied with the improved production of short-chain fatty acids ( < 0.05). Moreover, the PICRUSt pathway analysis revealed that FTE upregulated genes enriched in pathways of the carbohydrate metabolism, signaling molecules and immune system. As a rising star of post-fermented teas with the low cost, high accessibility and confirmed health benefits, our findings indicate the beneficial impacts of Fu brick tea on the promotion of adipose browning and thermogenesis in association with gut microbiota reconstructions, paving the way to restrict obesity and its associated metabolic diseases.
茯砖茶是最著名的微生物发酵茶之一，因其具有显著的抗肥胖能力而备受关注；然而，其作用机制在很大程度上仍未得到探索。在此，我们观察到茯砖茶水提物（FTE）在 8 周的口服给药中，能够剂量依赖性地降低高脂肪饮食（HFD）喂养小鼠的体重和腹股沟白色脂肪组织中异常脂肪堆积，刺激棕色脂肪组织中的米色脂肪发育和产热（<0.05）。FTE 改善了 HFD 诱导的肠道菌群失调，并改善了微生物组生态，从而增强了降低宿主肥胖、异常糖代谢和肝脂肪变性的能力。FTE 增加了有益菌菌株的丰度，、、、、、、、，伴随着短链脂肪酸产量的增加（<0.05）。此外，PICRUSt 途径分析显示，FTE 上调了富含碳水化合物代谢、信号分子和免疫系统途径的基因。作为一种具有低成本、高可及性和已证实健康益处的后发酵茶的新兴明星，我们的研究结果表明，茯砖茶对促进脂肪褐变和产热以及肠道微生物组重构有有益影响，为限制肥胖及其相关代谢性疾病铺平了道路。
