from Fu Brick Tea Promotes Adipose Thermogenesis by Boosting Colonic in High-Fat-Fed Obese Mice.

This study investigated the potential fat-thermogenic effects of , and elucidated the underlying mechanisms. The 12-week administration of in HFD-fed obese mice reduced body weight and improved glucolipid metabolism disorders. The administration of also efficiently promoted thermogenesis by increasing the expression of UCP1 and PRDM16 in both interscapular brown adipose tissue (iBAT) and inguinal white adipose tissue (iWAT) of HFD-fed mice. Furthermore, shaped the gut microbiome by increasing the abundance of and , and also elevated the levels of cecal short-chain fatty acids, particularly propionate and acetate. Of note, was highly negatively correlated with body weight gain (r = -0.801, < 0.05) and the iWAT index (r = -0.977, < 0.01), suggesting that may play an important role in the thermogenic mobilization induced by . Continuous supplementation with suppressed adipose accumulation, improved glucolipid metabolism, and enhanced the thermogenic activity of iWAT and iBAT. Collectively, our results propose that boosted acts as a key microbe in tea-derived probiotic -mediated fat-thermogenic and anti-obesity effects.