Fan Lei, Song Chao, Lu Ximing, Wang Tong, Han Jie, Guo Rong
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China.
Soft Matter. 2022 Oct 19;18(40):7859-7865. doi: 10.1039/d2sm01105k.
Arthritis is a disease that seriously affects the quality of human life, which is partly caused by the reduction of joint lubrication performance. Thus, for the treatment of arthritis, how to improve the lubrication performance of joints is important. The lamellar liquid crystals (LLCs) systems have the potential to be used as joint lubrication due to their double-layer structure and good biocompatibility, however, the LLCs system alone could not provide a satisfactory lubrication effect. Herein, this work synthesized hydroxyapatite (HAP) inside Tween 85/Tween 80/HO LLCs to construct a biocompatible HAP/Tween 85/Tween 80/HO LLCs (HAP/LLCs) lubrication system with both sustained drug release properties and anti-wear properties. HAP is the main component of bone with good stability and bioactivity. The LLCs have good lubricating and drug-carrying properties. The impact of HAP on the structure and lubrication properties of LLCs, the mechanism of friction, and the anti-wear reduction of HAP/LLCs were investigated. Moreover, the drug release behavior of the ibuprofen-loaded HAP/LLCs during the friction process was also studied. The results indicated that the addition of HAP could improve the lubricity performance of LLCs. The cumulative drug releasing increased with the friction frequency and was less affected by the load. The related studies provided the theoretical basis for HAP/LLCs for joint lubrication and synergistic therapy.
关节炎是一种严重影响人类生活质量的疾病，部分原因是关节润滑性能下降。因此，对于关节炎的治疗，如何提高关节的润滑性能至关重要。层状液晶（LLCs）体系因其双层结构和良好的生物相容性而具有用作关节润滑的潜力，然而，单独的LLCs体系不能提供令人满意的润滑效果。在此，本工作在吐温85/吐温80/水的LLCs体系中合成了羟基磷灰石（HAP），以构建具有持续药物释放性能和抗磨损性能的生物相容性HAP/吐温85/吐温80/水的LLCs（HAP/LLCs）润滑体系。HAP是骨骼的主要成分，具有良好的稳定性和生物活性。LLCs具有良好的润滑和载药性能。研究了HAP对LLCs结构和润滑性能的影响、摩擦机理以及HAP/LLCs的抗磨损性能。此外，还研究了载布洛芬的HAP/LLCs在摩擦过程中的药物释放行为。结果表明，HAP的加入可以提高LLCs的润滑性能。累积药物释放量随摩擦频率增加而增加，且受载荷影响较小。相关研究为HAP/LLCs用于关节润滑和协同治疗提供了理论依据。
