Emmerson R Y, Dustman R E, Shearer D E, Chamberlin H M
Alcohol. 1987 Jul-Aug;4(4):241-8. doi: 10.1016/0741-8329(87)90018-8.
EEG, visually evoked potentials (VEP), and event related potentials (P300) were recorded from 60 males aged 25-40 (20 abstinent alcoholics, 20 social drinkers, and 20 lifetime nondrinkers). Alcoholics were at least 1 month abstinent, medication free, and neuropsychologically normal. Residual effects of alcohol abuse were not detected in EEG power and cortical coupling analyses, or VEP amplitude, latency, and amplitude/intensity slope measures. Only P300 measures, recorded while subjects were actively engaged in a visual oddball task (20% targets), differentiated alcoholics from nonalcoholics. Alcoholics had reduced N2-P3 amplitude and delayed N2 latencies compared to social drinkers and nondrinkers. Because P300 abnormalities have been reported for individuals with positive family history for alcoholism, it is not clear whether these results reflect familial influence or residual effects of alcohol abuse. Issues relating to age, health and medication status of abstinent alcoholics, and use of social drinkers as comparison groups in studies of brain dysfunction in "recovering" alcoholics are also discussed.
对60名年龄在25至40岁之间的男性进行了脑电图（EEG）、视觉诱发电位（VEP）和事件相关电位（P300）记录（其中20名戒酒者、20名社交饮酒者和20名终生不饮酒者）。戒酒者戒酒至少1个月，未服用药物，神经心理学检查正常。在脑电图功率和皮质耦合分析、视觉诱发电位幅度、潜伏期以及幅度/强度斜率测量中均未检测到酒精滥用的残留影响。只有在受试者积极参与视觉oddball任务（20%为目标刺激）时记录的P300测量结果能够区分戒酒者和非戒酒者。与社交饮酒者和不饮酒者相比，戒酒者的N2 - P3幅度降低，N2潜伏期延迟。由于有阳性酒精中毒家族史的个体也有P300异常的报道，所以尚不清楚这些结果是反映了家族影响还是酒精滥用的残留影响。还讨论了与戒酒者的年龄、健康和用药状况以及在“康复”戒酒者脑功能障碍研究中使用社交饮酒者作为对照组相关的问题。
