Porjesz B, Begleiter H, Bihari B, Kissin B
Electroencephalogr Clin Neurophysiol. 1987 Feb;66(2):121-31. doi: 10.1016/0013-4694(87)90181-7.
The latencies of the N2 component of the ERP and reaction time were manipulated in abstinent alcoholics and controls. The experimental design consisted of visual stimuli that differed in difficulty of discrimination. N2 latencies were found to be significantly delayed in alcoholics compared to controls, particularly for the easy discrimination. While controls manifested significantly earlier N2 latencies for the easy discrimination compared to the difficult discrimination, alcoholics did not manifest any significant difference in the latency of N2 as a function of the level of difficulty. There were no significant differences between groups in terms of RT or number of errors. In addition, alcoholics displayed significantly reduced P3 amplitudes to target stimuli compared to controls. These results suggest that match/mismatch processes are impaired in alcoholics and that they have difficulty evaluating the potential significance of a stimulus.
对戒酒的酗酒者和对照组的事件相关电位（ERP）N2成分的潜伏期和反应时间进行了操控。实验设计包括不同辨别难度的视觉刺激。结果发现，与对照组相比，酗酒者的N2潜伏期显著延迟，尤其是在简单辨别任务中。虽然对照组在简单辨别任务中的N2潜伏期明显早于困难辨别任务，但酗酒者的N2潜伏期并未因难度水平而表现出任何显著差异。两组在反应时间或错误数量方面没有显著差异。此外，与对照组相比，酗酒者对目标刺激的P3波幅显著降低。这些结果表明，酗酒者的匹配/不匹配过程受损，他们在评估刺激的潜在重要性方面存在困难。
