Begleiter H, Porjesz B, Rawlings R, Eckardt M
Alcohol. 1987 Jul-Aug;4(4):315-21. doi: 10.1016/0741-8329(87)90029-2.
We have previously reported P3 decrements in boys at risk for alcoholism in a complex visual rotation reaction time task. The present study investigated the generalizability of these observations by studying a new high risk sample of boys of Type 2 alcoholic fathers under different experimental conditions. The current experimental design consisted of an easy auditory oddball task (P3) which stressed accuracy over speed of responding, and which also included variable interstimulus intervals (0.5, 1.0 and 5.0 sec), allowing recovery functions to be derived from the evoked responses to frequent non-target stimuli. The results did not yield statistically significant differences between groups in the recovery function data. However the baseline-to-peak results to the target stimulus indicated significant decreases in both P2 and P3 amplitudes in the high risk boys. No differences in latency were obtained between groups. Furthermore frequency analysis of responses to the target stimulus using a multivariate time series model indicated between-group differences at 4 frequencies (1.43, 7.14, 8.6 and 11.43 Hz). These results replicate our previous findings of P3 decrements in boys at risk for alcoholism in a new sample of sons of Type 2 alcoholics. As we have now made these observations with different experimental conditions and sensory modalities, it is suggested that these findings are generalizable.
我们之前曾报道，在一项复杂的视觉旋转反应时间任务中，有酗酒风险的男孩存在P3波幅降低的情况。本研究通过在不同实验条件下研究一类新的高风险样本——父亲为2型酗酒者的男孩，来探究这些观察结果的普遍性。当前的实验设计包括一项简单的听觉Oddball任务（P3），该任务更强调反应的准确性而非速度，并且还包括可变的刺激间隔（0.5、1.0和5.0秒），从而能够从对频繁出现的非目标刺激的诱发反应中得出恢复函数。结果显示，两组在恢复函数数据上没有统计学上的显著差异。然而，对目标刺激的基线到峰值结果表明，高风险男孩的P2和P3波幅均显著降低。两组之间在潜伏期上没有差异。此外，使用多元时间序列模型对目标刺激的反应进行频率分析，结果显示在4个频率（1.43、7.14、8.6和11.43赫兹）上存在组间差异。这些结果在一类新的2型酗酒者儿子的样本中重复了我们之前关于有酗酒风险的男孩存在P3波幅降低的发现。由于我们现在是在不同的实验条件和感觉模态下进行这些观察的，因此表明这些发现具有普遍性。
